EIF3F Human
目录号 : GP23381Eukaryotic Translation Initiation Factor 3F Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Eukaryotic Translation Initiation Factor 3; Subunit F; EIF3S5 ; Eukaryotic Translation Initiation Factor 3; Subunit 5 (Epsilon; 47kD); EC 3.4.19.12; Deubiquitinating Enzyme EIF3f; eIF3f; eIF-3-epsilon; EIF3 P47; Eukaryotic Translation Initiation Factor 3 Subunit 5; eIF3-p47; Eukaryotic Translation Initiation Factor 3; Subunit 5 Epsilon; 47kDa. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMATPAVP VSAPPATPTP VPAAAPASVP APTPAPAAAP VPAAAPASSS DPAAAAAATA APGQTPASAQ APAQTPAPAL PGPALPGPFP GGRVVRLHPV ILASIVDSYE RRNEGAARVI GTLLGTVDKH SVEVTNCFSV PHNESEDEVA VDMEFAKNMY ELHKKVSPNE LILGWYATGH DITEHSVLIH EYYSREAPNP IHLTVDTSLQ NGRMSIKAYV STLMGVPGRT MGVMFTPLTV KYAYYDTERI GVDLIMKTCF SPNRVIGLSS DLQQVGGASA RIQDALSTVL QYAEDVLSGK VSADNTVGRF LMSLVNQVPK IVPDDFETML NSNINDLLMV TYLANLTQSQ IALNEKLVNL. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | EIF3F protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, and 0.4M urea. | ||
Eukaryotic Translation Initiation Factor 3F, alsoknown as EIF3F belongs to the eIF-3 subunit F family. EIF3F is a component ofthe eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for several steps in the initiation of proteinsynthesis. The eIF-3 complex associates with the 40S ribosome andfacilitates the recruitment of eIF-1, eIF-1A, eIF 2: GTP: methionyl-tRNAi andeIF-5 to form the 43S preinitiation complex (43S PIC). Inaddition, the eIF-3 complex stimulates mRNA recruitment to the 43S PIC andscanning of the mRNA for AUG recognition. TheeIF-3 complex is also necessary for disassembly and recycling of posttermination ribosomal complexes and subsequently preventspremature union of the 40S and 60S ribosomal subunits prior to initiation. Among the diseases associated with EIF3F are intrahepaticcholangiocarcinoma, and cholangiocarcinoma.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.