Elubiol
(Synonyms: dichlorophenyl imidazoldioxolan) 目录号 : GC25374Elubiol (dichlorophenyl imidazoldioxolan) is used as a cosmetic ingredient for the conditioning of oily skin, effective in oil control.
Cas No.:67914-69-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Elubiol (dichlorophenyl imidazoldioxolan) is used as a cosmetic ingredient for the conditioning of oily skin, effective in oil control.
| Cas No. | 67914-69-6 | SDF | Download SDF |
| 别名 | dichlorophenyl imidazoldioxolan | ||
| 分子式 | C27H30Cl2N4O5 | 分子量 | 561.46 |
| 溶解度 | DMSO: 15 mg/mL (26.72 mM);; | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7811 mL | 8.9054 mL | 17.8107 mL |
| 5 mM | 0.3562 mL | 1.7811 mL | 3.5621 mL |
| 10 mM | 0.1781 mL | 0.8905 mL | 1.7811 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Modulation of sebum excretion from the follicular reservoir by a dichlorophenyl-imidazoldioxolan
Int J Cosmet Sci 1996 Oct;18(5):219-27.PMID:19245450DOI:10.1111/j.1467-2494.1996.tb00152.x.
Synopsis The dichlorophenyl-imidazoldioxolan Elubiol is used for skin and hair care in subjects with oily skin or dandruff. A study was conducted in 14 men to evaluate by non-invasive methods the effect of long-term use of Elubiol on the sebum output at the skin surface. Measures were made using the Sebumeter SM810 and Sebutapes. Data show a progressive decrease in skin oiliness at the forehead site treated by Elubiol compared to the contralateral control site. The function of the follicular reservoir appears to be affected without significant primary change in the sebaceous gland activity.
Comparative anti-dandruff efficacy between a tar and a non-tar shampoo
Dermatology 2000;200(2):181-4.PMID:10773717DOI:10.1159/000018362.
A randomized double-blind clinical study was conducted on two groups of 30 volunteers using either a non-tar shampoo (2% salicylic acid, 0.75% piroctone olamine and 0.5% Elubiol) or a 0.5% coal tar shampoo. Subjects were diagnosed as having moderate to marked dandruff. The study consisted of a 3-week washout, followed by a 4-week treatment and a 4-week posttreatment regression phase. The clinical evaluations and subject self-assessments showed that the non-tar shampoo was as effective as the tar shampoo. Both received high approval ratings (> or =70%). Biometrological methods proved to be more sensitive than clinical evaluations to assess the efficacy of the shampoos. The non-tar shampoo yielded a significantly better reduction of Malassezia spp. counts (p<0.02) during the treatment phase and reduced the spontaneous increase in squamometry values (p< 0.01) during the posttreatment phase. It is concluded that a formulation associating salicylic acid, piroctone olamine and Elubiol exhibited increased beneficial effects compared to the coal tar shampoo.
New insight into the topical management of excessive sebum flow at the skin surface
Dermatology 1998;196(1):126-9.PMID:9557246DOI:10.1159/000017845.
The sebum flow dynamics at the skin surface results from a multistep process starting with sebocyte proliferation, intracellular lipid synthesis, cell lysis in the sebaceous duct, storage of sebum in the follicular reservoir, discharge through the follicular opening and spreading over the stratum corneum. A handful of topical products may decrease the sebum output, most of them acting at the level of the follicular reservoir function. Among them, Elubiol exhibits a clinically relevant effect on oily skin.