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Endosulfan II Sale

(Synonyms: BETA-硫丹) 目录号 : GC43605

An organochlorine insecticide

Endosulfan II Chemical Structure

Cas No.:33213-65-9

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10mg
¥428.00
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25mg
¥857.00
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50mg
¥1,284.00
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Quality Control & SDS

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产品描述

Endosulfan II is an organochlorine insecticide and a stereoisomer of endosulfan I. It is active against a variety of insects including bollworms and tobacco budworms (LD50s = 4.14 and 4.95 mg/g, respectively). Endosulfan II binds to GABA receptors in rat brain membranes with an IC50 value of 60 nM and is less toxic to rats than endosulfan I (LD50s = 240 and 18 mg/kg, respectively).

Chemical Properties

Cas No. 33213-65-9 SDF
别名 BETA-硫丹
Canonical SMILES Cl[C@]1(C2(Cl)Cl)[C@]([H])(CO[S@](OC3)=O)[C@@]3([H])[C@]2(Cl)C(Cl)=C1Cl
分子式 C9H6Cl6O3S 分子量 406.9
溶解度 Chloroform: Slightly Soluble,Methanol: Slightly Soluble 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4576 mL 12.288 mL 24.5761 mL
5 mM 0.4915 mL 2.4576 mL 4.9152 mL
10 mM 0.2458 mL 1.2288 mL 2.4576 mL
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Research Update

Persistent endosulfan sulfate is found with highest abundance among endosulfan I, II, and sulfate in German forest soils

Environ Pollut 2015 Nov;206:661-6.PMID:26319511DOI:10.1016/j.envpol.2015.08.023.

Endosulfan - an agricultural insecticide and banned by Stockholm Convention - is produced as a 2:1 to 7:3 mixture of isomers endosulfan I (ESI) and Endosulfan II (ESII). Endosulfan is transformed under aerobic conditions into endosulfan sulfate (ESS). The study shows for 76 sampling locations in German forests that endosulfan is abundant in all samples with an opposite ratio between the ESI and ESII than the technical product, where the main metabolite ESS is found with even higher abundance. The ratio between ESI/ESII and ESS show clear dependence on the type of stands (coniferous vs. deciduous) and humus type and increases from deciduous via mixed to coniferous forest stands. The study argues for a systematic monitoring of ESI, ESII, and ESS and underlines the need for further research, specifically on the fate of endosulfan including biomagnifications and bioaccumulation in soil.

Putative interactions between transthyretin and Endosulfan II and its relevance in breast cancer

Int J Biol Macromol 2023 Apr 30;235:123670.PMID:36796556DOI:10.1016/j.ijbiomac.2023.123670.

The unregulated use of organochlorine pesticides (OCPs) has been linked to spread of breast cancer (BC), but the underlying biomolecular interactions are unknown. Using a case-control study, we compared OCP blood levels and protein signatures among BC patients. Five pesticides were found in significantly higher concentrations in breast cancer patients than in healthy controls: p',p' dichloro diphenyl trichloroethane (DDT), p'p' dichloro diphenyl dichloroethane (DDD), Endosulfan II, delta-hexachlorocyclohexane (dHCH), and heptachlor epoxide A (HTEA). According to the odds ratio analysis, these OCPs, which have been banned for decades, continue to raise the risk of cancer in Indian women. Proteomic analysis of plasma from estrogen receptor-positive breast cancer patients revealed 17 dysregulated proteins, but transthyretin (TTR) was three times higher than in healthy controls, which is further validated by enzyme-linked immunosorbent assays (ELISA). Molecular docking and molecular dynamics studies revealed a competitive affinity between Endosulfan II and the thyroxine-binding site of TTR, pointing towards the significance of the competition between thyroxin and endosulfan, resulting in endocrine disruption leading to breast cancer. Our study sheds light on the putative role of TTR in OCP-mediated BC, but more research is needed to decipher the underlying mechanisms that can be used to prevent the carcinogenic effects of these pesticides on women's health.

Concentration, distribution, and human health risk assessment of endosulfan from a manufacturing facility in Huai'an, China

Sci Total Environ 2014 Sep 1;491-492:163-9.PMID:24491393DOI:10.1016/j.scitotenv.2014.01.050.

Endosulfan concentrations and its distribution in air, soil, sediment and foodstuffs in the area surrounding a production facility in Huai'an, China were investigated because of its threats to the environment and human health. Air concentrations for endosulfan Ι, Endosulfan II and endosulfan sulfate measured in this study were several orders of magnitude higher than those reported previously for this region. Surface soil concentration ranges of endosulfan I, Endosulfan II, and endosulfan sulfate were greater than in sediment. Endosulfan II was the greatest contributor to total endosulfan concentrations in both surface sediment and soil followed by endosulfan sulfate and endosulfan Ι. However, a different concentration profile was observed in fish and crop samples, with endosulfan sulfate having the highest concentration followed by endosulfan I and Endosulfan II. The concentration of Σendosulfans (endosulfans Ι and II) in soil decreased rapidly with increasing distance from the plant by a factor of 10 within 45 km. Trace amounts of Σendosulfans were observed in deep soil layers which implied that these compounds are transported through the leaching of pore water in soil. This demonstrated that emissions from the manufacturing facility can lead to ground water contamination in the area near the plant. A screening level human health risk assessment of Σendosulfans based on the worst-case scenario was performed for people living in the vicinity of the manufacturing facility. The hazard indices were at least 2 orders of magnitude of <1, indicating no adverse health effects are likely to occur at current exposure levels, and the risk to human health is generally acceptable.

Bioaccumulation of endosulfan (Thiodan insecticide) in the tissues of Louisiana crayfish, Procambarus clarkii

J Environ Sci Health B 1990 Aug;25(4):511-26.PMID:2243172DOI:10.1080/03601239009372703.

The bioaccumulation potential of endosulfan was determined by constantly exposing male and female adult crayfish, Procambarus clarkii to 100 ppb Thiodan insecticide for 8 wks. The crayfish were removed at 2 wk intervals and the uptake by tissues (whole-body) was determined by electron capture gas-chromatography. The same number of pre-exposed crayfish (100 ppb Thiodan) were transferred to endosulfan-free water after 8 wks, and insecticide loss (depuration) was similarly quantitated. The maximum amount of insecticide and its metabolites detected after 8 wks were 197 ppb Endosulfan II, 18 ppb endosulfan I and 3 ppb endosulfan sulfate. During the first 4 wks of depuration, endosulfan loss from cryfish tissues occurred rapidly, and only 3 ppb endosulfan I remained. No Endosulfan II and sulfate were detected beyond 4 wks. The residues in male vs female were not significant statistically. Bioaccumulation factor (BF) for Endosulfan II for crayfish tissues was 1.97, which is considerably lower than for other aquatic invertebrates (26 for scallop, Chlamys opercularis and 600 for mussel, Mytilus edulis. The presence of endosulfan sulfate in the tissues cannot be considered as 'detoxification' which is as toxic as the parent compound.

Endosulfan and its metabolites in fertile women, placenta, cord blood, and human milk

Environ Res 2005 Jun;98(2):233-9.PMID:15820730DOI:10.1016/j.envres.2004.08.008.

Although industrialized nations have restricted or banned many organochlorine pesticides, some of these chemicals (e.g., endosulfans) are still used, on the assumption that they pose little threat to the environment, wildlife, or human health. According to available information, Spain is the main consumer of endosulfans within the European Union, accounting for almost half of the total consumption. Reports on human exposure in Southern Spain to persistent bioacumulable organochlorine pesticides have indicated considerable exposure to endosulfans. The present study investigated the presence of endosulfan I, Endosulfan II, and endosulfan metabolites in fatty and non-fatty tissues and fluids from women of reproductive age and children in Southern Spain. The highest concentration of commercial endosulfan I and Endosulfan II was found in adipose tissue, with a mean value (I+II) of 17.72 ng/g lipid, followed by human milk, with a mean value (I+II) of 11.38 ng/mL milk. These findings support the lipophilicity of these chemicals and their elimination by milk secretion. The concentration in the placenta homogenate was similar to that in the blood from the umbilical cord (7.74 and 6.11 ng/mL, respectively) and reflected their lower fat content. Endosulfan diol and endosulfan sulfate were more frequently found in placenta homogenate, with a mean concentration of 12.56 and 3.57 ng/mL, respectively, and in blood from umbilical cord, at 13.23 and 2.82 ng/mL, respectively. Therefore, women of reproductive age in Southern Spain appear to be currently exposed to endosulfans. Because these chemicals can be mobilized during pregnancy and lactation, further research is warranted to investigate the health consequence in children resulting from exposure to chemicals suspected of immunotoxic, neurotoxic, or endocrine-disrupting effects.