(-)-Epigallocatechin gallate (EGCG)

Name: (-)-Epigallocatechin gallate (EGCG)
SKU: GC14049
Availability: InStock
Rating: 5 (30 reviews)

(Synonyms: (-)-表没食子儿茶素没食子酸酯,EGCG) 目录号 : GC14049

(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。

(-)-Epigallocatechin gallate (EGCG) Chemical Structure

Cas No.:989-51-5

规格价格库存购买数量

10mM (in 1mL DMSO)	¥399.00	现货
100mg	¥389.00	现货
500mg	¥1,439.00	现货

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Sample solution is provided at 25 µL, 10mM.

GlpBio产品文献引用

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

产品描述实验参考方法化学性质产品文档相关产品

Description

(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis[1-2]. EGCG has free radical scavenging properties[3]. EGCG has anti-inflammatory and anti-apoptotic effects against oxidative stress in neurons[4].In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2)^[5].

(-)- Epigallocatechin Gallate(EGCG) (200 µM; 1 h) downregulates expression levels of pro-inflammatory cytokine and mediators in CoCl2-treated BV2 cells[6]. EGCG inhibits 3T3-L1 cell growth via miR-143/MAPK7 pathway[7].

(-)- Epigallocatechin Gallate(EGCG) (5 -30 mg/kg; i.g; 14 days) reduces tumor(HT-29 colorectal cancer) growth[8]. EGCG treatment(50 mg/kg per day) dissolved in corn oil was administrated via intraperitoneal injection from day 7 to 11 at 1 h before house dust mite (HDM) challenge) relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages[9].

References:
[1]. Jin CF, Shen SR Sr, et,al. Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. J Agric Food Chem. 2001 Dec;49(12):6033-8. doi: 10.1021/jf010903r. PMID: 11743804.
[2]. De Amicis F, Perri A, et,al. Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Oct;228(10):2054-62. doi: 10.1002/jcp.24372. PMID: 23553645.
[3]. Kondo K, Kurihara M, et,al. Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action. Free Radic Biol Med. 1999 Oct;27(7-8):855-63. doi: 10.1016/s0891-5849(99)00133-1. PMID: 10515590.
[4]. Schroeder EK, Kelsey NA, et,al. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal. 2009 Mar;11(3):469-80. doi: 10.1089/ars.2008.2215. PMID: 18754708.
[5]. Peeters TH, Lenting K, et,al. Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. Cancer Metab. 2019 May 20;7:4. doi: 10.1186/s40170-019-0198-7. PMID: 31139406; PMCID: PMC6526618.
[6]. Kim SR, Seong KJ, et,al. Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation. Int J Mol Sci. 2022 Apr 4;23(7):4004. doi: 10.3390/ijms23074004. PMID: 35409364; PMCID: PMC8999549.
[7]. Chen CP, Su TC, et,al. Green tea epigallocatechin gallate suppresses 3T3-L1 cell growth via microRNA-143/MAPK7 pathways. Exp Biol Med (Maywood). 2022 Sep;247(18):1670-1679. doi: 10.1177/15353702221108925. Epub 2022 Jul 27. PMID: 35894140; PMCID: PMC9597208.
[8]. Jin H, Gong W, et,al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. doi: 10.2147/OTT.S40914. Epub 2013 Mar 8. PMID: 23525843; PMCID: PMC3596123.
[9]. Yang N, Li X. Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages. Biochem Pharmacol. 2022 Aug;202:115112. doi: 10.1016/j.bcp.2022.115112. Epub 2022 May 29. PMID: 35640712.

(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡[1-2]。EGCG具有清除自由基的特性[3]。EGCG对神经元氧化应激具有抗炎和抗凋亡作用[4]。此外,它还能抑制谷氨酸脱氢酶1/2 (GDH1/2, GLUD1/2)的活性[5]。

(-)-Epigallocatechin Gallate sulfate (EGCG) (200 µM; 1 h)下调CoCl2处理BV2细胞中促炎细胞因子和介质的表达水平[6]。(-)-Epigallocatechin Gallate sulfate (EGCG)通过miR-143/MAPK7途径抑制3T3-L1细胞生长[7]。

(-)-Epigallocatechin Gallate sulfate (EGCG) (5 -30 mg/kg; i.g; 14 days)减少肿瘤(HT-29结直肠癌)的生长[8]。(-)-Epigallocatechin Gallate sulfate (EGCG)治 (50 mg/kg / d)溶解于玉米油中,于第7天至第11天室内尘螨(HDM)处理前1 h腹腔注射)通过抑制HIF-1α/ vegfa介导的巨噬细胞M2偏移来缓解小鼠哮喘症状[9]。

实验参考方法

Cell experiment [1]:
Cell lines	BV2 cells
Preparation Method	Cells were treated with EGCG (200 µM) for 1 h prior to CoCl2 (350 µM) exposure for 8 h.
Reaction Conditions	200 µM; 1 h
Applications	(-)- Epigallocatechin Gallate(EGCG) downregulates expression levels of pro-inflammatory cytokine and mediators in CoCl2-treated BV2 cells.
Animal experiment [2]:
Animal models	BALB/c nude mice (carried HT-29 colorectal cancer)
Preparation Method	In the therapeutic group, 5 -20 mg/kg of EGCG was administrated intragastrically, and in the control group, 100 uL of physiological saline was administrated intragastrically, once daily for 14 days.
Dosage form	5 -30 mg/kg; i.g; 14 days
Applications	(-)- Epigallocatechin Gallate(EGCG) reduces tumor growth.
References: [1]. Kim SR, Seong KJ, et,al. Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation. Int J Mol Sci. 2022 Apr 4;23(7):4004. doi: 10.3390/ijms23074004. PMID: 35409364; PMCID: PMC8999549. [2]. Jin H, Gong W, et,al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. doi: 10.2147/OTT.S40914. Epub 2013 Mar 8. PMID: 23525843; PMCID: PMC3596123.

化学性质

Cas No.	989-51-5	SDF
别名	(-)-表没食子儿茶素没食子酸酯,EGCG
化学名	[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Canonical SMILES	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
分子式	C₂₂H₁₈O₁₁	分子量	458.37
溶解度	≥ 22.9mg/mL in DMSO; ≥ 20mg/mL in Water	储存条件	Store at -20°C
General tips	请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。
Shipping Condition	评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。

溶解性数据

制备储备液
		1 mg	5 mg	10 mg
	1 mM	2.1816 mL	10.9082 mL	21.8164 mL
	5 mM	0.4363 mL	2.1816 mL	4.3633 mL
	10 mM	0.2182 mL	1.0908 mL	2.1816 mL

摩尔浓度计算器
稀释计算器
分子量计算器

计算

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % saline

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系GLPBIO）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。

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Quality Control & SDS

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Purity: >98.00%