EPOR Human, Active
目录号 : GP20199Erythropoietin Receptor Human Recombinant, Active
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by analysis by SDS-PAGE. | Source | Sf9, Baculovirus cells. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | EPO-R; EPOR; Erythropoietin Receptor. | ||
| Amino Acid Sequence | APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGPGNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVLLDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRTRYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Biological Activity | Measured by its ability to inhibit EPO dependentproliferation assay using TF-1 human erythroleukemic cells. The ED50 for thiseffect less or equal to 70ng/ml. | ||
| Formulation | EPOR protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. | ||
Erythropoietin receptor, also known as EPOR arbitrates erythropoietin-induced erythroblast proliferation as well as differentiation. During EPO binding, EPOR activates Jak2 tyrosine kinase which activates various intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. Furthermore, stimulated EPOR has a function in erythroid cell survival. Mutations in EPOR may possibly produce erythroleukemia and familial erythrocytosis. In addition, dysregulation of EPOR can affect on the growth of selected tumors.
Measured by its ability to inhibit EPO dependentproliferation assay using TF-1 human erythroleukemic cells. The ED50 for thiseffect less or equal to 70ng/ml.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.