EPOR Human
目录号 : GP20198Erythropoietin Receptor Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 95.0% as determined by SDS-PAGE. | Source | Sf9,Baculovirus cells. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Erythropoietin Receptor; EPO-R; EPOR. Normal 0 false false false EN-US X-NONE HE MicrosoftInternetExplorer4--> | ||
| Amino Acid Sequence | APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGPGNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVLLDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARMAEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH. Normal 0 false false false EN-US X-NONE HE --> | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | EPOR protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. Normal 0 false false false EN-US X-NONE HE --> | ||
Erythropoietinreceptor, also known as EPOR arbitrates erythropoietin-induced erythroblastproliferation as well as differentiation. During EPO binding, EPOR activates Jak2tyrosine kinase which activates various intracellular pathways including:Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors.Furthermore, stimulated EPOR has a function in erythroid cell survival. Mutationsin EPOR may possibly produce erythroleukemia and familial erythrocytosis. Inaddition, dysregulation of EPOR can affect on the growth of selected tumors.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.