Eriodictyol-7-O-glucoside

Eriodictyol 7-O-glucoside is a flavanone glucoside that has been found in V. coloratum and has diverse biological activities.^1,2,3 It scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC₅₀s = 0.28 and 0.3 mM, respectively).¹ Eriodictyol 7-O-glucoside activates nuclear factor E2-related factor 2 (Nrf2) in a reporter assay.² It protects against cytotoxicity induced by cisplatin in human renal mesangial cells (HRMCs), but not A549 lung or MDA-MB-231 breast cancer cells, when used at a concentration of 80 ?M. Eriodictyol 7-O-glucoside (30 mg/kg) attenuates neurological deficits and reduces infarct volume in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).³

1.Yao, H., Liao, Z.-X., Wu, Q., et al.Antioxidative flavanone glycosides from the branches and leaves of Viscum coloratumChem. Pharm. Bull. (Tokyo)54(1)133-135(2006) 2.Hu, Q., Zhang, D.D., Wang, L., et al.Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicityFood Chem. Toxicol.50(6)1927-1932(2012) 3.Jing, X., Ren, D., Wei, X., et al.Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injuryToxicol. Appl. Pharmacol.273(3)672-679(2013)