Erythorbic acid
(Synonyms: D-异抗坏血酸,D-Isoascorbic acid; D-Araboascorbic acid) 目录号 : GC39657
Erythorbic acid (D-Isoascorbic acid) 是一种主要用于肉类、家禽和软饮料的食品添加剂，由不同来源的糖 (如甜菜、甘蔗和玉米) 制成。
Cas No.:89-65-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Erythorbic acid (D-Isoascorbic acid), produced from sugars derived from different sources, such as beets, sugar cane, and corn, is a food additive used predominantly in meats, poultry, and soft drinks.
| Cas No. | 89-65-6 | SDF | |
| 别名 | D-异抗坏血酸,D-Isoascorbic acid; D-Araboascorbic acid | ||
| Canonical SMILES | O=C1C(O)=C(O)[C@]([C@H](O)CO)([H])O1 | ||
| 分子式 | C6H8O6 | 分子量 | 176.12 |
| 溶解度 | DMSO: 125 mg/mL (709.74 mM); Water: 83.33 mg/mL (473.14 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.6779 mL | 28.3897 mL | 56.7795 mL |
| 5 mM | 1.1356 mL | 5.6779 mL | 11.3559 mL |
| 10 mM | 0.5678 mL | 2.839 mL | 5.6779 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Erythorbic acid is a potent enhancer of nonheme-iron absorption
Am J Clin Nutr 2004 Jan;79(1):99-102.PMID:14684404DOI:10.1093/ajcn/79.1.99.
Background: Erythorbic acid, a stereoisomer of ascorbic acid with similar physicochemical properties, is widely used as an antioxidant in processed foods. Objectives: The aims of the present study were to evaluate the effect of Erythorbic acid on iron absorption from ferrous sulfate at molar ratios of 2:1 and 4:1 (relative to iron) and to compare the effect of Erythorbic acid directly with that of ascorbic acid at a molar ratio of 4:1. Design: Iron absorption from iron-fortified cereal was measured in 10 women on the basis of erythrocyte incorporation of stable iron isotopes ((57)Fe or (58)Fe) 14 d after administration. Each woman consumed 4 ferrous-sulfate-fortified test meals (containing 5 mg Fe/meal) with or without added erythorbic or ascorbic acid. The data were evaluated by use of paired t tests, and the results are presented as geometric means. Results: Iron absorption from the test meal without any added enhancer was 4.1%. The addition of Erythorbic acid (at molar ratios of 2:1 and 4:1 relative to iron) increased iron absorption 2.6-fold (10.8%; P < 0.0001) and 4.6-fold (18.8%; P < 0.0001), respectively. The addition of ascorbic acid (molar ratio of 4:1) increased iron absorption 2.9-fold (11.7%; P = 0.0004). At a molar ratio of 4:1, Erythorbic acid was 1.6-fold (P = 0.0002) as potent an enhancer of iron absorption as was ascorbic acid. Conclusion: Although Erythorbic acid is a potent enhancer of iron absorption, its lack of antiscorbutic activity limits its usefulness in iron-fortification programs. However, it may play a major role in enhancing iron bioavailability from mixed diets that include foods preserved with Erythorbic acid.
Effects of Erythorbic acid on vitamin C metabolism in young women
Am J Clin Nutr 1996 Sep;64(3):336-46.PMID:8780343DOI:10.1093/ajcn/64.3.336.
Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States as a food additive. Studies were conducted to determine whether the ingestion of Erythorbic acid in the diet had any beneficial or adverse effects on the human requirement for vitamin C. Young women were fed diets that contained controlled amounts of Erythorbic acid and ascorbic acid. In pharmacokinetic evaluations, Erythorbic acid and ascorbic acid were rapidly absorbed with little interaction. Erythorbic acid cleared from the body more rapidly than ascorbic acid. Some subjects received diets deficient in vitamin C for periods < or = 30 d. Increasing intakes of Erythorbic acid or prolonged intakes of < or = 1 g Erythorbic acid/d did not indicate any interactions with ascorbic acid. Consumption of Erythorbic acid resulted in the presence of Erythorbic acid in mononuclear leukocytes. Ascorbic acid concentrations in these cells were not affected by the presence of Erythorbic acid. Erythorbic acid disappeared quickly from these cells with cessation of Erythorbic acid supplements. Prolonged ingestion of erythrobic acid by young women neither antagonized nor spared their vitamin C status.
Effect of smoking on Erythorbic acid pharmacokinetics
Br J Nutr 2003 May;89(5):667-71.PMID:12720586DOI:10.1079/BJN2003840.
Considerable evidence exists that smoking significantly lowers the concentration of plasma antioxidants. While for most antioxidants this effect appears to result mainly from altered dietary habits, ascorbic acid has recently been shown to be depleted by smoking per se. However, the direct cause of ascorbate depletion remains unclear. Erythorbic acid is a stereoisomer of ascorbic acid commonly used as antioxidant in foodstuffs and has the same redox properties as ascorbic acid. We therefore investigated if Erythorbic acid could be used as a non-isotopic marker of smoking-induced oxidative stress. In a sample of smokers (n 10) and non-smokers (n 10), the pharmacokinetics of Erythorbic acid were followed after a single oral dose (1 g) and subsequently, the effect of a 2-week ascorbic acid supplementation (0.5 g/d) on Erythorbic acid kinetics was studied in a double-blind, placebo-controlled fashion. There were no significant effects of smoking or supplementation on relative bioavailability (difference in area under curve, AUC 0-infinity) of Erythorbic acid (smokers 357 (sd 119), non-smokers 414 (sd 142) micromol.h/l; P=0.34). Time to reach maximum plasma concentration (Tmax) was significantly less in smokers (P=0.03). If the relative pharmacokinetics of Erythorbic acid between smokers and non-smokers compares with those of AA, our present results do not suggest that altered pharmacokinetics is likely to play a major role in the ascorbic acid depletion consistently observed in smokers.
Interaction of Erythorbic acid with ascorbic acid catabolism
Int J Vitam Nutr Res 1976;46(1):40-7.PMID:1262134doi
After a vitamin C depletion period of 12 days supplementing Erythorbic acid (50 mg/day/kg bodyweight) over 16 days significantly accelerated the catabolism of a newly ingested tracer dose of (1-14C) ascorbic aicd in guinea pigs in comparison to animals supplemented with ascorbic acid (5 mg/day/kg bodyweight), but this effect of Erythorbic acid could not be normalized by additional supplementation with ascorbic acid. Half-lives for (1-14C) ascorbic acid (50% of the dose excreted) were drastically reduced from 97 h to 50 h and 59 h, respectively. Also figures on the retention of radioactivity showed the availability of ascorbic acid to be reduced. This is in accordance with the significant reduction in size of ascorbic acid bodypool, and in weight gain in the groups receiving Erythorbic acid, or erythorbic and ascorbic acids. The bioavailability was calculated to be strongly depressed to nearly 50% of the total ingested biologically active material (ascorbic plus erythorbic acids), assuming Erythorbic acid to have only one-twentieth of the biological activity of ascorbic acid.
Influence of Erythorbic acid on ascorbic acid retention and elimination in the mouse
Int J Vitam Nutr Res 1983;53(3):258-64.PMID:6629665doi
Large quantities of ascorbic acid or Erythorbic acid were administered to Swiss mice over a period of seven months. Urinary ascorbic acid and Erythorbic acid were determined two weeks before termination of the experiment. At the end of the experiment, ascorbic acid and Erythorbic acid contents in plasma, liver and brain tissues were measured. In the ascorbic acid-treated mice, there was a marked elevation in plasma and urine ascorbate levels, and there was a 38% increase of ascorbate level in the liver but there was no substantial increase in ascorbate levels in the four brain regions studied, namely the cerebrum, cerebellum, medulla and brain stem, upon large intake of ascorbic acid. In the erythorbic acid-treated mice, Erythorbic acid is well absorbed by the gastrointestinal tract, enters the blood stream, and is rapidly excreted in the urine. The results show that Erythorbic acid is able to replace 45% of ascorbic acid in the liver and 28-39% of ascorbic acid in the brain tissues. Although Erythorbic acid appears in the blood at significantly high level, it does not lower blood ascorbate levels.