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Esculin (hydrate) Sale

(Synonyms: Aesculin, Enallachrome) 目录号 : GC47306

A coumarin with antioxidant and anti-inflammatory activities

Esculin (hydrate) Chemical Structure

规格 价格 库存 购买数量
5 g
¥496.00
现货
10 g
¥891.00
现货
25 g
¥1,987.00
现货
50 g
¥3,477.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Esculin is a coumarin that has been found in A. hippocastanum and has antioxidant and anti-inflammatory activities.1,2 It reduces the size of gastric ulcers and decreases increases in the levels of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) and catalase in a mouse model of ethanol-induced ulcers when used at a dose of 25 mg/kg.1 Esculin (20 mg/kg) decreases LPS-induced increases in the levels of TLR4, MyD88, IRAK4, and phosphorylated NF-?B in the lung, as well as levels of IL-1β, IL-6, and TNF-α in the bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.2

1.Rios, E.R., Rocha, N.F., VenÂncio, E.T., et al.Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in miceChem. Biol. Interact.188(1)246-254(2010) 2.Tianzhu, Z., and Shumin, W.Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-κB pathwaysInflammation38(4)1529-1536(2015)

化学性质

Cas No. N/A SDF
别名 Aesculin, Enallachrome
Canonical SMILES O=C1C=CC2=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C(O)C=C2O1.O
分子式 C15H16O9.XH2O 分子量 340.3
溶解度 DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.9386 mL 14.6929 mL 29.3858 mL
5 mM 0.5877 mL 2.9386 mL 5.8772 mL
10 mM 0.2939 mL 1.4693 mL 2.9386 mL
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