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Estramustine phosphate sodium Sale

(Synonyms: 雌莫司汀磷酸钠) 目录号 : GC32816

A derivative of estradiol that destabilizes microtubules

Estramustine phosphate sodium Chemical Structure

Cas No.:52205-73-9

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10mm*1mlinwater
¥324.00
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5mg
¥261.00
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10mg
¥352.00
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25mg
¥581.00
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50mg
¥786.00
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100mg
¥1,061.00
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Sample solution is provided at 25 µL, 10mM.

Description

Estramustine phosphate is a derivative of estradiol that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 ?M for MAP-1 and MAP-2, respectively.1 Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells.2,3 The metabolites of estramustine phosphate have anti-androgenic effects.4 Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.

1.Tew, K.D., and Stearns, M.E.Estramustine--a nitrogen mustard/steroid with antimicrotubule activityPharmacol. Ther.43(3)299-319(1989) 2.Hartley-Asp, B.Estramustine-induced mitotic arrest in two human prostatic carcinoma cell lines DU 145 and PC-3Prostate5(1)93-100(1984) 3.Yoshida, D., Hoshino, S., Shimura, T., et al.Drug-induced apoptosis by anti-microtubule agent, estramustine phosphate on human malignant glioma cell line, U87MG; in vitro studyJ. Neurooncol.47(2)133-140(2000) 4.Wang, L.G., Liu, X.M., Kreis, W., et al.Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptorBiochem. Pharmacol.55(9)1427-1433(1998)

化学性质

Cas No. 52205-73-9 SDF
别名 雌莫司汀磷酸钠
Canonical SMILES [O-]P([O-])(O[C@H]1CC[C@@]2([H])[C@@]3([H])[C@](C(C=CC(OC(N(CCCl)CCCl)=O)=C4)=C4CC3)([H])CC[C@@]21C)=O.[Na+].[Na+]
分子式 C23H30Cl2NNa2O6P 分子量 564.35
溶解度 Water : 62.5 mg/mL (110.75 mM);DMSO : 5 mg/mL (8.86 mM) 储存条件 4°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.772 mL 8.8598 mL 17.7195 mL
5 mM 0.3544 mL 1.772 mL 3.5439 mL
10 mM 0.1772 mL 0.886 mL 1.772 mL
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