Etersalate (Eterylate)
(Synonyms: 依特柳酯,Eterylate; Etherylate) 目录号 : GC32540Etersalate (Eterylate) 抑制血小板功能并降低血栓素 A2 (TXA2) 水平。
Cas No.:62992-61-4
Sample solution is provided at 25 µL, 10mM.
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Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
Ex vivo antiplatelet properties of Etersalate and its effects on serum thromboxane A2 (TXA2) levels and prostaglandin I2 (PGI2) generation are studied in human volunteers at two levels of oral dosing. Etersalate inhibits at the lower dosage platelet function and decreased TXA2 levels, but PGI2 generation from rat aortic rings is stimulated when incubated with plasma from Etersalate-treated donors. Blood coagulation parameters remain within normal values. Etersalate administration can act on platelet arachidonate metabolism at a different level than that of the cyclooxygenase pathway[1].
[1]. Ortega MP, et al. Effect of etersalate on human platelet responsiveness. A study in healthy volunteers. Arzneimittelforschung. 1987 Feb;37(2):214-7.
Cas No. | 62992-61-4 | SDF | |
别名 | 依特柳酯,Eterylate; Etherylate | ||
Canonical SMILES | O=C(OCCOC1=CC=C(NC(C)=O)C=C1)C2=CC=CC=C2OC(C)=O | ||
分子式 | C19H19NO6 | 分子量 | 357.36 |
溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg | |
1 mM | 2.7983 mL | 13.9915 mL | 27.983 mL |
5 mM | 0.5597 mL | 2.7983 mL | 5.5966 mL |
10 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Effect of Etersalate on human platelet responsiveness. A study in healthy volunteers
Arzneimittelforschung 1987 Feb;37(2):214-7.PMID:2883981doi
Ex vivo antiplatelet properties of 2-(p-acetamido-phenoxy)ethyl-o-acetoxybenzoate (Etersalate, Daital) and its effects on serum thromboxane A2 (TXA2) levels and prostaglandin I2 (PGI2) generation were studied in human volunteers at two levels of oral dosing. Etersalate inhibited at the lower dosage platelet function and decreased TXA2 levels, but PGI2 generation from rat aortic rings was stimulated when incubated with plasma from etersalate-treated donors. Blood coagulation parameters remained within normal values. It is suggested that Etersalate administration could act on platelet arachidonate metabolism at a different level than that of the cyclooxygenase pathway.