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Ethylparaben (Ethyl parahydroxybenzoate) Sale

(Synonyms: 羟苯乙酯; Ethyl parahydroxybenzoate; Ethyl 4-hydroxybenzoate) 目录号 : GC30447

A paraben with diverse biological activities

Ethylparaben (Ethyl parahydroxybenzoate) Chemical Structure

Cas No.:120-47-8

规格 价格 库存 购买数量
100mg
¥84.00
现货
10mM (in 1mL DMSO)
¥92.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Ethylparaben is a paraben that has been found in A. bracteatus and has diverse biological activities.1,2,3,4 It selectively induces activation of estrogen receptor β (ERβ) over ERα in yeast two-hybrid assays (EC50s = 1.86 and 38.2 ?M, respectively). Ethylparaben inhibits carbonic anhydrase I (CAI), CAII, CAVII, CAIX, CAXII, and CAXIV (IC50s = 7.9, 4.8, 8.7, 8.2, 8.6, and 7.7 ?M, respectively, for the human enzymes).2 It is active against several strains of P. stutzeri and P. aeruginosa (MICs = 400-1,000 ?g/ml).3 Ethylparaben (0.01 and 0.1%) is cytotoxic to immortalized human meibomian gland epithelial cells.4 It has been found in influent and effluent wastewater.5 Formulations containing ethylparaben have been used as preservatives in cosmetics, food, and pharmaceuticals.

1.Cao, X., Jiang, J., Zhang, S., et al.Discovery of natural estrogen receptor modulators with structure-based virtual screeningBioorg. Med. Chem. Lett.23(11)3329-3333(2013) 2.Carta, F., Vullo, D., Maresca, A., et al.Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIVBioorg. Med. Chem.21(6)1564-1569(2013) 3.Tattawasart, U., Maillard, J.-Y., Furr, J.R., et al.Comparative responses of Pseudomonas stutzeri and Pseudomonas aeruginosa to antibacterial agentsJ. Appl. Microbiol.87(3)323-331(1999) 4.Wang, J., Liu, Y., Kam, W.R., et al.Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cellsExp. Eye Res.196108057(2020) 5.Wang, W., and Kannan, K.Fate of parabens and their metabolites in two wastewater treatment plants in New York state, United StatesEnviron. Sci. Technol.50(3)1174-1181(2016)

化学性质

Cas No. 120-47-8 SDF
别名 羟苯乙酯; Ethyl parahydroxybenzoate; Ethyl 4-hydroxybenzoate
Canonical SMILES O=C(OCC)C1=CC=C(O)C=C1
分子式 C9H10O3 分子量 166.17
溶解度 DMSO : ≥ 1.7 mg/mL (10.23 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 6.0179 mL 30.0897 mL 60.1793 mL
5 mM 1.2036 mL 6.0179 mL 12.0359 mL
10 mM 0.6018 mL 3.009 mL 6.0179 mL
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