Etofenprox
(Synonyms: 醚菊酯) 目录号 : GC60825
A non-ester pyrethroid insecticide
Cas No.:80844-07-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Etofenprox is a non-ester pyrethroid insecticide.1 It induces toxicity in the housefly M. domestica (LD50 = 23 ng/fly). Etofenprox (0.005-0.02%) induces 100% mortality in green leafhopper adults and brown planthopper and white-backed planthopper nymphs on rice plants within 24 hours of application.2 It is toxic to the aquatic invertebrate D. magna (EC50 = 1.2 μg a.s./L) and the fish O. mykiss (LC50 = 2.7 μg a.s./L) but not rats (LD50 = >2,000 mg/kg).3 Formulations containing etofenprox have been used in the control of agricultural pests.
1.Pedersen, L.-E.K.The potency of cyclopropane pyrethroid ethers against susceptible and resistant strains of the house fly Musca domesticaExperientia42(9)1057-1058(1986) 2.Krishnaiah, N.V., and Kalode, M.B.Efficacy of ethofenprox against leafhoppers and planthoppers, with emphasis on preventing resurgence of brown planthopper, Nilaparvata lugens (St?l), in riceCrop Prot.12(7)532-538(1993) 3.Authority, E.F.S.Conclusion regarding the peer review of the pesticide risk assessment of the active substance etofenproxEFSA Scientific Report2131-131(2008)
| Cas No. | 80844-07-1 | SDF | |
| 别名 | 醚菊酯 | ||
| Canonical SMILES | CC(C)(C1=CC=C(OCC)C=C1)COCC2=CC=CC(OC3=CC=CC=C3)=C2 | ||
| 分子式 | C25H28O3 | 分子量 | 376.49 |
| 溶解度 | DMSO: 100 mg/mL (265.61 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6561 mL | 13.2806 mL | 26.5611 mL |
| 5 mM | 0.5312 mL | 2.6561 mL | 5.3122 mL |
| 10 mM | 0.2656 mL | 1.3281 mL | 2.6561 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Residual characteristics of Etofenprox in the processing stages of rice cakes and cookies
PLoS One 2021 Aug 6;16(8):e0255751.PMID:34358278DOI:10.1371/journal.pone.0255751.
The changes in residual amounts of an insecticide (Etofenprox) in processed rice cakes and cookies were investigated in this study. Test samples were sprayed with Etofenprox during rice cultivation, and brown rice samples were dipped in a pesticide solution to investigate the effects of washing and processing. A multiresidue method for multiclass pesticides was employed for Etofenprox analysis using a high-performance liquid chromatography-ultraviolet detector setup. Etofenprox was not detected in polished rice that was processed into rice cakes and cookies. The Etofenprox residue levels were 2.13 mg/kg in each processing stage of brown rice products that were dipped in 400 mg/kg Etofenprox solutions. The residual amounts of Etofenprox in washed/polished rice and rice flour obtained by grinding were 1.25 and 0.77 mg/kg, respectively. The residual levels were 0.38 mg/kg in rice cakes prepared by cooking rice flour in a steamer for 20 min (a decrease of 82.1% compared to that in polished rice), 0.47 mg/kg in rice cookies baked in an oven for 20 min (a decrease of 78.0%), and 0.21 mg/kg in fried rice cookies (a decrease of 90.2%). Overall, the residual levels of Etofenprox decreased in a range of 40-100% during the processing of rice cakes and cookies.
Etofenprox as grain protectant for the management of five key stored-product insect pests
Environ Sci Pollut Res Int 2022 Mar;29(15):21547-21560.PMID:34761320DOI:10.1007/s11356-021-17212-z.
Etofenprox is a broad spectrum pyrethroid insecticide with low toxicity to mammals, fishes, and honeybees. In the present study it was evaluated as grain protectant against Ephestia kuehniella (Lepidoptera: Pyralidae) larvae, Prostephanus truncatus (Coleoptera: Bostrychidae) adults, Rhyzopertha dominica (Coleoptera: Bostrychidae) adults, Sitophilus oryzae (Coleoptera: Curculionidae) adults, and Tribolium confusum (Coleoptera: Tenebrionidae) larvae and adults. Etofenprox was applied at 0.1, 1, 5, and 10 ppm on wheat, or maize in the case of P. truncatus, and tested at different combinations of temperatures (20, 25, and 30 °C) and relative humidity (RH) levels (55 and 75%). Progeny production of the tested coleopteran adult species was also assessed. For E. kuehniella, after 21 days of exposure 75.6% of the exposed larvae were killed at 20 and 30 °C/55% RH. Mortality of P. truncatus adults reached 99.4 and 97.8% at 10 ppm of 55 and 75% RH, respectively, at 30 °C. For S. oryzae, after 21 days of exposure, mortality was moderate at both RH levels, even at the elevate doses, reaching 66.7% at 10 ppm at 20°C/75% RH. All R. dominica adults died 21 days post-exposure at 30°C/55% RH and 25 or 30°C/75% RH at 10 ppm. For T. confusum adults, mortality was 81.1% 10 ppm 21 days post-exposure at 20°C/75% RH. Etofenprox killed 99.4% of the exposed T. confusum larvae at 10 ppm respectively 14 days post-exposure at 25°C/55% RH. Concerning progeny production, complete suppression was recorded for P. truncatus, R. dominica, and T. confusum in various combinations of temperature/RH. Our findings indicate that Etofenprox is a well-promising insecticide for the protection of stored grains. However, its performance differs among insect species and abiotic conditions.
Insecticidal properties of Etofenprox for the control of Ephestia kuehniella, Rhyzopertha dominica, Sitophilus oryzae, and Tribolium confusum on stored barley, maize, oats, rice, and wheat
Environ Sci Pollut Res Int 2022 Dec;29(56):84256-84267.PMID:35779218DOI:10.1007/s11356-022-21342-3.
Etofenprox is a novel pyrethroid insecticide that targets the nervous system of insects by affecting the function of the sodium channel. The current study examines the insecticidal activity of Etofenprox against Ephestia kuehniella (Lepidoptera: Pyralidae) larvae, Rhyzopertha dominica (Coleoptera: Bostrychidae) adults, Sitophilus oryzae (Coleoptera: Curculionidae) adults, and Tribolium confusum (Coleoptera: Tenebrionidae) adults and larvae on different grain commodities. For this purpose, Etofenprox was applied on barley, maize, oats, rice, and wheat at 0.1, 1, 5, and 10 ppm. Mortality levels were recorded after 7, 14, and 21 days of exposure. For E. kuehniella larvae, 10 ppm applied on whole rice killed 96.1% of the exposed individuals after 21 days of exposure. The application of Etofenprox on oats at 5 ppm caused the death of 98.3% of the exposed R. dominica adults. Complete mortality was observed for R. dominica adults 21 days post-exposure to oats and whole rice treated with 10 ppm Etofenprox. The highest concentration applied on barley caused 95.0% mortality to S. oryzae adults, while the same concentration on maize killed 76.8% of T. confusum adults after 21 days of exposure. Larvae of T. confusum exhibited high mortality levels reaching 99.4% after 21 days of exposure to barley treated with 10 ppm Etofenprox. Progeny production of parental R. dominica adults was almost suppressed on all commodities treated with 5 ppm Etofenprox. The offspring emergence of S. oryzae ranged between 4.4 and 24.6 adults per vial at 10 ppm. No T. confusum progeny was produced at 10 ppm Etofenprox. Our results document that Etofenprox is highly effective as grain protectant against several insect species, their developmental stages and their progeny production, but its performance depends on the type of the commodity that it is applied on.
Identification of permethrin and Etofenprox cross-tolerance in Rhipicephalus sanguineus sensu lato (Acari: Ixodidae)
Pest Manag Sci 2019 Oct;75(10):2794-2801.PMID:30809952DOI:10.1002/ps.5391.
Background: The brown dog tick, Rhipicephalus sanguineus sensu lato (Latreille; Acari: Ixodidae), is a peridomestic ectoparasite of dogs and occasionally humans. In some populations, lack of integrated pest management practices and overuse of pesticides has resulted in high levels of resistance to multiple active ingredients. In this study, we established the Etofenprox discriminating concentration (DC) and three additional screening concentrations to evaluate resistance status. Using mortality results, cross-resistance was investigated in brown dog tick populations from five geographically disparate regions, including Asia, Africa, Europe, North America, and the Caribbean, following exposure to the DC for both Etofenprox and permethrin separately. Subsequently, using both larval packet tests and molecular methods, Etofenprox resistance was investigated. Results: The Etofenprox DC was set at 0.51%, which allows for the rapid screening of peridomestic brown dog tick populations for resistance to this active ingredient. Cross-tolerance to two sodium channel-inhibiting pesticides, permethrin and Etofenprox, was observed in one population. Conclusion: Our study has provided a single Etofenprox concentration that can be used in larval packet tests to determine resistance status in collected peridomestic brown dog ticks, which is particularly important when a single to a few engorged adult ticks are provided for evaluation. Although metabolic resistance is presumed to be the primary resistance mechanism, a sodium channel mutation also confers tolerance to Etofenprox at the DC. © 2019 Society of Chemical Industry.
Metabolic resistance in Nilaparvata lugens to Etofenprox, a non-ester pyrethroid insecticide
Pestic Biochem Physiol 2017 Mar;136:23-28.PMID:28187826DOI:10.1016/j.pestbp.2016.08.009.
Etofenprox, a non-ester pyrethroid insecticide, will be registered to control rice pests such as the brown planthopper (BPH, Nilaparvata lugens Stål) in mainland China. Insecticide resistance is always a problem to the effective control of N. lugens by chemical insecticides. An Etofenprox resistance selection of N. lugens was performed in order to understand the related mechanisms. Through successive selection by Etofenprox for 16 generations in the laboratory, an etofenprox-resistant strain (G16) with the resistance ratio (RR) of 422.3-fold was obtained. The resistance was partly synergised (2.68-fold) with the metabolic inhibitor PBO, suggesting a role for P450 monooxygenases. In this study, 11 P450 genes were significantly up-regulated in G16, among which eight genes was above 2.0-fold higher than that in US16, a population with the same origin of G16 but without contacting any insecticide in the laboratory. The expression level of four genes (CYP6AY1, CYP6FU1 and CYP408A1 from Clade 3, and CYP425A1 from Clade 4) were above 4.0-fold when compared to US16. RNA interference (RNAi) was performed to evaluate the importance of the selected P450s in Etofenprox resistance. When CYP6FU1, CYP425A1 or CYP6AY1 was interfered, the susceptibility was significantly recovered in both G16 and US16, while the knockdown of CYP408A1 or CYP353D1 did not cause significant changes in Etofenprox susceptibility. We supposed that CYP6FU1 was the most important P450 member for Etofenprox resistance because of the highest expression level and the most noticeable effects on resistance ratios following RNAi.