Exendin-3 (9-39) amide (trifluoroacetate salt)
(Synonyms: Exendin (9-39)) 目录号 : GC91862Exendin-3 (9-39) amide is a truncated form of the exendin-4 (48-86) amide peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Exendin-3 (9-39) amide is a truncated form of the exendin-4 (48-86) amide peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).[1] It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM).[2] Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 µg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.[3]
References:
[1].Thorens, B., Porret, A., Bühler, L., et al.Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptorDiabetes42(11)1678-1682(1993).
[2].Ruffman, J.-P., Singh, L., and Eng, J.Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonistJ. Biol. Chem.266(5)2897-2908(1991).
[3].Turton, M.D., O'Shea, D., Gunn, I., et al.A role for glucagon-like peptide-1 in the central regulation of feedingNature379(6560)69-72(1996).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.2968 mL | 1.4838 mL | 2.9675 mL |
| 5 mM | 0.0594 mL | 0.2968 mL | 0.5935 mL |
| 10 mM | 0.0297 mL | 0.1484 mL | 0.2968 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。