Famoxadone
(Synonyms: 恶唑菌酮,DPX-JE874) 目录号 : GC61441
A fungicide
Cas No.:131807-57-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Famoxadone is a fungicide.1 It inhibits mitochondrial complex III, also known as the cytochrome bc1 complex, and electron transport in rat heart submitochondria (IC50s = 28 and 4.5 ng/ml, respectively). It reduces oxygen consumption in, and induces disintegration of, P. infestans zoospores when used at a concentration of 2 ?g/ml. Famoxadone inhibits the growth of P. viticola on grape seedlings (EC50 = 3 ?g/ml). Formulations containing famoxadone have been used to control various fungal diseases in crops.
1.Jordan, D.B., Livingston, R.S., Bisaha, J.J., et al.Mode of action of famoxadonePestic. Sci.55105-118(1999)
| Cas No. | 131807-57-3 | SDF | |
| 别名 | 恶唑菌酮,DPX-JE874 | ||
| Canonical SMILES | O=C(N1NC2=CC=CC=C2)OC(C3=CC=C(OC4=CC=CC=C4)C=C3)(C)C1=O | ||
| 分子式 | C22H18N2O4 | 分子量 | 374.39 |
| 溶解度 | DMSO: 100 mg/mL (267.10 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.671 mL | 13.3551 mL | 26.7101 mL |
| 5 mM | 0.5342 mL | 2.671 mL | 5.342 mL |
| 10 mM | 0.2671 mL | 1.3355 mL | 2.671 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Chiral Fungicide Famoxadone: Stereoselective Bioactivity, Aquatic Toxicity, and Environmental Behavior in Soils
J Agric Food Chem 2021 Aug 4;69(30):8530-8535.PMID:34313440DOI:10.1021/acs.jafc.1c00825.
In this study, the stereoselective bioactivity, acute toxicity, and environmental fate for Famoxadone enantiomers were reported for the first time. Five representative pathogens (e.g., Alternaria solani) were used to investigate enantioselective activity, and three non-target organisms (e.g., Selenastrum bibraianum) were used to evaluate acute toxicity. S-Famoxadone was 3.00-6.59 times more effective than R-famoxadone. R-Famoxadone also showed 1.80-6.40 times more toxicity than S-famoxadone toward S. bibraianum and Daphnia magna. The toxicity of R-famoxadone was 100 times more toxic than S-famoxadone toward Danio rerio. Under aerobic conditions, the half-life (t1/2) for Famoxadone enantiomer degradation was 46.2-126 days in different soils and the enantiomeric fraction (EF) ranged from 0.435 to 0.470 after 120 days. R-Famoxadone preferentially degraded in three soils, resulting in an enrichment of S-famoxadone. Under anaerobic conditions, t1/2 of Famoxadone enantiomers was 62.4-147 days in different soils and the EF ranged from 0.489 to 0.495, indicating that Famoxadone enantiomers were not enantioselective. This study will be useful for the environmental and health risk assessments for Famoxadone enantiomers.
Enantioselective fate of Famoxadone during processing of apple cider and grape wine
Chirality 2021 Mar;33(3):134-142.PMID:33460199DOI:10.1002/chir.23296.
Famoxadone enantiomers were separated on Lux Amylose-1 chiral column and determined by ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS). The half-lives of R-(-)-famoxadone and S-(+)-famoxadone were 69.3 and 86.6 h in apple cider, 231.0 and 346.5 h in apple pomace, 69.3 and 77.0 h in grape wine, and 231.0 and 346.5 h in grape pomace, respectively. The enantiomeric fraction (EF) values decreased gradually from 0.498, 0.499, and 0.500 (0 h) to 0.404, 0.374, and 0.427 (144 h) and then increased gradually to 0.474, 0.427, and 0.422 (312 h) in apple cider, grape wine, and grape pomace. The EF value in apple pomace decreased gradually from 0.499 (0 h) to 0.450 (168 h) and then increased gradually to 0.482 (312 h). The processing factors (PFs) for Famoxadone ranged from 0.014 to 0.024 in the overall process. The residue of Famoxadone reduced 94.7-97.4% after the fermentation process.
Enantioselective degradation of Myclobutanil and Famoxadone in grape
Environ Sci Pollut Res Int 2018 Jan;25(3):2718-2725.PMID:29134531DOI:10.1007/s11356-017-0539-4.
The enantioselective degradation of myclobutanil and Famoxadone enantiomers in grape under open field was investigated in this study. The absolute configuration of myclobutanil and Famoxadone enantiomers was determined by the combination of experimental electronic circular dichroism (ECD) and calculated ECD spectra. The enantiomers residues of myclobutanil and Famoxadone in grape were measured by sensitive high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). The linearity, precision, accuracy, matrix effect, and stability were assessed. And the limit of quantification (LOQ) for each enantiomer of myclobutanil and Famoxadone in grape was evaluated to be 1.5 and 2 μg kg-1. The myclobutanil and Famoxadone showed the enantioselective degradation in grape, and the enantioselectivity of degradation for myclobutanil was more pronounced than that for Famoxadone. The half-lives were 13.1 days and 25.7 days for S-(+)-myclobutanil and R-(-)-myclobutanil in grape, separately. The half-life of S-(+)-famoxadone was 31.5 days slightly shorter than that of R-(-)-famoxadone with half-life being 38.5 days in grape. The probable reasons for the enantioselective degradation behavior of these two fungicides were also discussed. The results in the article might provide a reference to better assess the risks of myclobutanil and Famoxadone enantiomers in grapes to human and environment. Graphical abstract The enantioselective analysis of myclobutanil and Famoxadone in grape.
Famoxadone residue and dissipation in watermelon and soil
Ecotoxicol Environ Saf 2010 Feb;73(2):183-8.PMID:19836076DOI:10.1016/j.ecoenv.2009.08.003.
The residue levels and dissipation rate of Famoxadone in watermelon and soil were determined by HPLC-UVD. The LODs for Famoxadone in watermelon, peel, flesh and soil were 0.002mg/kg (0.004mg/kg in leaf). The fortified recoveries ranged from 84.91% to 99.41% with relative standard deviations (RSDs) of 0.06-4.50%. The dissipation of Famoxadone residue over the time in watermelon leaf and soil fitted to the equation C(T)=19.695e(-0.078T) and C(T)=1.369e(-0.129T). The half-lives (T(1/2)) of Famoxadone in watermelon leaf and soil were 9.7 and 5.5 days, respectively. The final residue in watermelon was lower than 0.1mg/kg at harvest, which suggested the use of this fungicide to be safe to both human and environment. This work would be helpful in establishing the maximum residue limit (MRL) for Famoxadone in watermelon in China, and provide guidance to the proper and safe use of this pesticide in agriculture.
Uptake, Translocation, and Subcellular Distribution of Oxathiapiprolin and Famoxadone in Tomato Plants ( Lycopersicon esculentum Miller)
J Agric Food Chem 2022 Oct 5;70(39):12310-12319.PMID:36134436DOI:10.1021/acs.jafc.2c03668.
The uptake, translocation, and subcellular distribution of oxathiapiprolin and Famoxadone in tomato plants were investigated using hydroponic experiments. Oxathiapiprolin and Famoxadone mainly accumulated in the tomato roots with limited translocation capacity from the roots to the upper part. The root absorption and inhibitor results noted the dominance of the apoplastic and symplastic pathways in the oxathiapiprolin and Famoxadone uptake by the tomato roots, respectively. Furthermore, the uptake process for the two fungicides followed passive and aquaporin-dependent transport. Insoluble cell components (cell organelles and walls) were the dominant storage compartments for oxathiapiprolin and Famoxadone. In the protoplast, oxathiapiprolin in the soluble fraction had a higher proportion than that of Famoxadone. Finally, the uptake and distribution of the two fungicides by the tomato plants was accurately predicted using a partition-limited model. Thus, this study provides an in-depth understanding of the transfer of oxathiapiprolin and Famoxadone from the environment to tomato plants.