Fenchlorphos
(Synonyms: 皮蝇磷) 目录号 : GC32258
Fenchlorphos用于防治家畜体外寄生虫。
Cas No.:299-84-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fenchlorphos is used to prevent and cure the parasitic in veterinary medicine.
| Cas No. | 299-84-3 | SDF | |
| 别名 | 皮蝇磷 | ||
| Canonical SMILES | S=P(OC)(OC)OC1=CC(Cl)=C(Cl)C=C1Cl | ||
| 分子式 | C8H8Cl3O3PS | 分子量 | 321.55 |
| 溶解度 | DMSO : 100 mg/mL (310.99 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1099 mL | 15.5497 mL | 31.0994 mL |
| 5 mM | 0.622 mL | 3.1099 mL | 6.2199 mL |
| 10 mM | 0.311 mL | 1.555 mL | 3.1099 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The effect of O,O-dimethyl-O-(2,4,5-trichlorophenyl) phosphorothioate (Fenchlorphos) on cholinesterases in the blue fox (Alopex lagopus)
Acta Vet Scand 1977;18(3):408-15.PMID:71852DOI:10.1186/BF03548438.
Four blue fox bitches were used in the experiments. Two foxes were given Fenchlorphos in the feed, one 100 mg/kg body weight and the other 200 mg/kg daily for 30 days. The maximum inhibition of plasma Cholinesterase was 65 and 69 %, respectively. The corresponding values of the erythrocyte acetylcholinesterase were 43 and 63 %. For the third bitch given 0.4 mg/kg as a single dose i.v. the effect was only measurable as a small transient decrease of the plasma Cholinesterase level. Eighty % of the plasma Cholinesterase of the fourth fox, given 500 mg/kg as a single oral dose, was inhibited on the third day. The erythrocyte acetylcholinesterase activity level only showed a slight decline. This fox vomited during feeding the day after administration. Symptoms as salivation, tremors, diarrhea, pinpoint pupils and respiratory distress were never seen in any of the foxes. It was concluded that Fenchlorphos administration in the feed in doses recommended to dogs is well tolerated by healthy foxes as far as Cholinesterase inhibition is concerned.
Teratogenicity and embryotoxicity of orally administered Fenchlorphos in blue foxes
Acta Vet Scand 1983;24(1):99-112.PMID:6191556DOI:10.1186/BF03546761.
Pregnant blue foxes (Alopex lagopus) were administered Fenchlorphos (0-0-dimethyl-0-(2,4,5-trichlorophenyl) phos-phorothioate) orally at a dose of 100 mg/kg/day in different periods of gestation. The dose chosen represents the therapeutic dose for the treatment of parasitic lesions. At term the mean number of whelps were recorded, and they were killed and examined for external, visceral and skeletal malformations. Of 19 medicated vixens the mean number of live whelps at term was 1.2 per vixen versus 9.5 in the control group. There was an evident predominance of males in the medicated groups. Several malformations of the head were registered, among them incomplete ossification of the skull bones, cleft palate, hydrocephalus internus and externus. Minor malformations like extra ribs or missing ribs occurred in the medicated groups. Congenital alopecia, hypoplastic kidneys, and hydronephrosis were observed in all the whelps in 1 medicated group. No significant difference in total brain weight, cerebellum weight or the cerebellum-to-total-brain weight was observed. Histological examination of the cerebellum showed a narrowing or absence of the granular and the molecular layers of the cortical zone.
[Determination of dermafos (Fenchlorphos) residues in the tissues of hens and rabbits after single oral dose of pure and technical preparations]
Pol Arch Weter 1981;23(1):143-57.PMID:6170958doi
The level of dermaphos residues in the blood, liver and the fat tissue was examined after a single oral application of the pure and technical preparation of various doses in hens and rabbits. An appropriately adapted method of extraction and purification and thin-layer chromatography for its quantitative determination were used. It was shown that the preparation, as well as some of its metabolites and contaminants had a tendency of prolonged accumulation in the examined tissue mainly in fat. A month after the administration of higher doses of pure dermaphos (i.e. 0,250 g/kg of body weight, calculated as active component) the blood of rabbits still contained 0,12 mg/kg, the liver--0,10 mg/kg, and the kidney fat--3,14 mg/kg of the preparation. In hens a dose of 2,500 g/kg of body weight gave the following results: 0,60 mg/kg in the blood, 0,67 mg/kg in the liver and 8,34 mg/kg in the omental fat. This long-lasting accumulation of dermaphos in the tissues is most probably connected with the presence of the trichlorphenyl ring in the molecule. It was also noticed that the contaminants present in the technical preparation influenced to some extent the accumulation rate of dermaphos in certain tissues and this was observed especially after administration of higher doses. On the other hand, the dynamics of disappearance and the accumulation degree of dermaphos in the hen and rabbit tissues did not depend only on the type of the tissue, but also on the animal species and the level of the administered dose.
Ovarian and testicular function in the blue fox (Alopex lagopus) after oral administration of Fenchlorphos during the breeding season
Acta Vet Scand 1983;24(2):200-10.PMID:6193696DOI:10.1186/BF03546747.
The possible effect of Fenchlorphos, 0-0-dimethy1-0-(2.4.5-trichlorophenyl) phosphorothioate, upon the reproductive endocrinology in blue foxes (Alopex lagopus) was investigated. Five females were administered Fenchlorphos orally at a dose of 100 mg/kg daily from 10 days before oestrus and up to the 21st day of gestation. This dose represents the therapeutic dose for the treatment of sarcoptic mange. Blood samples were collected for the analyses of progesterone, oestradiol-17尾 and luteinizing hormone (LH) in plasma. The vixens were ovario-hysterectomized on day 23, except 1 animal in the control group which was operated on day 17. Additionally, sperm quality and mating performance in 3 male blue foxes, which were administered 100 mg/kg Fenchlorphos daily during the first 3 weeks of the mating season, were examined. Pregnancy was recorded in 2 medicated and 4 control animals. No pathological changes were observed in the uterus and the ovaries. The plasma concentrations of the hormones were similar to those obtained from the control group. No evidence of any disturbances concerning spermatogenesis in the males was observed. However, their libido appeared to be reduced. None of the males achieved a mating during and after the period of medication.
Cholinesterase activities in uterus of normal and Fenchlorphos treated blue foxes (Alopex lagopus) during various reproductive states
Acta Vet Scand 1988;29(1):117-23.PMID:2462338DOI:10.1186/BF03548400.
The uterine acetylcholinesterase and total cholinesterase (acetylcholinesterase plus butyrylcholinesterase) activities in normal and Fenchlorphos treated blue fox vixens were determined during various reproductive states. AChE and Total-ChE of non-medicated vixens in oestrus were about one half of those in anoestrus. In pregnant uteri (luteal phase) the activities were 25 % and 30% compared to anoestrus. In vixens given 100 mg/kg Fenchlorphos for 3 weeks during anoestrus, the remaining activity of AChE in uterus were in average 37%. Pregnant and non-pregnant vixens in the luteal phase medicated prior to mating and during time of implantation, displayed AChE activities which were only moderabely reduced (remaining activities 83% and 72% compared to medicated animals in anoestrus: remaining activity 37%). Plasma ChE-activity increased during pregnancy in the controls while enzyme activity was strongly reduced in animals given 100 mg/kg Fenchlorphos daily through the whole pregnancy. It was concluded that the previous reported embryotoxic effect of Fenchlorphos in the blue fox did not seem to be directed towards the moderate inhibition of the uterine cholinesterases.