Fenoprofen

Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).¹ It inhibits spontaneous and estradiol-stimulated prostaglandin F_2α release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF_2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.²

1.Patrono, C., Ciabattoni, G., and Grossi-Belloni, D.In vitro and in vivo inhibition of prostaglandin synthesis by fenoprofen, a non steroid anti-inflammatory drugPharmacol. Res. Commun.6(5)509-518(1974) 2.Agotegaray, M., Gumilar, F., Boeris, M., et al.Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: Promising insights in the treatment of chronic inflammatory diseasesBiomed. Res. Int.2014(2014)