FGG Human
目录号 : GP23493Fibrinogen Gamma Chain Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Fibrinogen gamma chain isoform gamma-A; Fibrinogen gammachain; PRO2061. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSYVATRDN CCILDERFGS YCPTTCGIAD FLSTYQTKVD KDLQSLEDILHQVENKTSEV KQLIKAIQLT YNPDESSKPN MIDAATLKSR KMLEEIMKYE ASILTHDSSI RYLQEIYNSNNQKIVNLKEK VAQLEAQCQE PCKDTVQIHD ITGKDCQDIA NKGAKQSGLY FIKPLKANQQ FLVYCEIDGS GNGWTVFQKRLDGSVDFKKN WIQYKEGFGH LSPTGTTEFW LGNEKIHLIS TQSAIPYALR VELEDWNGRT STADYAMFKVGPEADKYRLT YAYFAGGDAG DAFDGFDFGD DPSDKFFTSH NGMQFSTWDN DNDKFEGNCA EQDGSGWWMN KCHAGHLNGVYYQGGTYSKA STPNGYDNGI IWATWKTRWY SMKKTTMKII PFNRLTIGEG QQHHLGGAKQ AGDV. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | FGG protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT. | ||
Fibrinogen gamma chain isoform gamma-A (FGG) is the gamma component of fibrinogen, which is a blood-borne glycoprotein, comprised of 3 pairs of nonidentical polypeptide chains. FGG along with fibrinogen alpha (FGA) and fibrinogen beta (FGB) polymerizes to form an insoluble fibrin matrix. Following vascular injury, FGG is cleaved by thrombin to create fibrin, which is the most abundant component of blood clots. FGG functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Moreover, different cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, exhibit vasoconstrictor and chemotactic activities, and are mitogens for a number of cell types. Maternal fibrinogen is vital for successful pregnancy. FGG gene mutations lead to some disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Fibrin accumulation is also linked with infection, where it protects against IFNG-mediated hemorrhage.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.