Fluazifop-P-butyl
(Synonyms: 精吡氟禾草灵) 目录号 : GC61758
Fluazifop-P-butyl是一种来自芳基苯氧基丙酸酯的杀草剂，是一种乙酰辅酶A羧化酶(ACCase)抑制剂。
Cas No.:79241-46-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor[1].
[1]. Marcin Horbowicz, et al. Effect of Fluazifop-P-Butyl Treatment on Pigments and Polyamines Level Within Tissues of Non-Target Maize Plants. Pestic Biochem Physiol. 2013 Sep;107(1):78-85.
| Cas No. | 79241-46-6 | SDF | |
| 别名 | 精吡氟禾草灵 | ||
| Canonical SMILES | C[C@@H](OC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(OCCCC)=O | ||
| 分子式 | C19H20F3NO4 | 分子量 | 383.36 |
| 溶解度 | DMSO: 100 mg/mL (260.85 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6085 mL | 13.0426 mL | 26.0851 mL |
| 5 mM | 0.5217 mL | 2.6085 mL | 5.217 mL |
| 10 mM | 0.2609 mL | 1.3043 mL | 2.6085 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Fluazifop-P-butyl induced ROS generation with IAA (indole-3-acetic acid) oxidation in Acanthospermum hispidum D.C
Pestic Biochem Physiol 2017 Nov;143:312-318.PMID:29183607DOI:10.1016/j.pestbp.2017.10.005.
Acanthospermum hispidum D.C. was particularly susceptible to Fluazifop-P-butyl, an aryloxyphenoxypropionate herbicide, and the primary action site for the herbicide was shoot apical meristem, which is also the main site of indole-3-acetic acid (IAA) biosynthesis and action. Membrane lipid peroxidation caused by increasing levels of reactive oxygen species (ROS) was considered as an action mechanism of Fluazifop-P-butyl in A. hispidum. To further clarify the ROS inducing mechanism of Fluazifop-P-butyl in the plant, the interactions between Fluazifop-P-butyl and auxin compounds IAA or 2,4-dichlorophenoxyacetic acid (2,4-D) were studied. Haloxyfop-P-methyl, an AOPP herbicide which is inactive on A. hispidum, was used for comparison. The results showed that the growth inhibition and malondialdehyde or H2O2 increases induced by Fluazifop-P-butyl on A. hispidum were reversed by IAA or 2,4-D. The IAA content was decreased but the contents of three IAA oxidation metabolites, indole-3-methanol, indole-3-aldehyde and indole-3-carboxylic acid were increased by Fluazifop-P-butyl in A. hispidum, but not by haloxyfop-P-methyl. The growth of A. hispidum was not inhibited by three IAA oxidative compounds. Moreover, the activities of IAA oxidase and peroxidase were increased by Fluazifop-P-butyl but not by haloxyfop-P-methyl, and the increase was reversed by IAA or 2,4-D. We suggest that there is an antagonistic effect between Fluazifop-P-butyl and IAA or 2,4-D, and the IAA oxidation may be involved in the action mechanism of Fluazifop-P-butyl in A. hispidum.
Effect of main inorganic metal elements in Panax ginseng field soil on the photodegradation of Fluazifop-P-butyl
Environ Sci Pollut Res Int 2021 Oct;28(38):52901-52912.PMID:34018113DOI:10.1007/s11356-021-14091-2.
The widespread use of pesticides contributes to their existence in the environment. The compounds with photocatalytic activity in environmental matrixes play a significant effect on the photodegradation of pesticides. In order to clear the photolysis effects of the main characteristic inorganic metal elements in the of Panax ginseng field soil on Fluazifop-P-butyl, a series of tests were carried out. The obtained results indicated that Mn2+ and Sn+ exhibited a significant photosensitization on the ultraviolet photodegradation of Fluazifop-P-butyl. Also the high content of VO3- and Mo7O246- in the photolysis system showed a photoquenching on Fluazifop-P-butyl, but the low content is a photosensitive effect. However, in the photolysis system, as the concentration of Co2+ and Li+ increases, the photoquenching effect on Fluazifop-P-butyl becomes obvious, and no photosensitization at any tested concentration of them.
Enantioselective behaviour of the herbicide fluazifop-butyl in vegetables and soil
Food Chem 2017 Apr 15;221:1120-1127.PMID:27979068DOI:10.1016/j.foodchem.2016.11.048.
The enantioselective dissipation of the enantiomers of fluazifop-butyl in tomato, cucumber, pakchoi, rape and soil under field condition was investigated to elucidate the enantioselective environmental behaviours and chiral stability of the optical pure product. Fluazifop, the major chiral metabolite of fluazifop-butyl, was also detected. Fluazifop-butyl dissipated rapidly in the vegetables and soil with the half-lives of the enantiomers ranging from 1.62 to 2.84days. Enantioselective degradations of fluazifop-butyl were found. In tomato and cucumber, S-fluazifop-butyl dissipated faster than R-enantiomer, while R-fluazifop-butyl showed a faster degradation in pakchoi, rape and soil. Fluazifop was found almost immediately after the application of fluazifop-butyl and had relatively longer persistent time. When the optical pure product Fluazifop-P-butyl was applied, rapid degradation to R-fluazifop was found with half-lives from 1.24 to 2.28days, and no S-fluazifop-butyl or S-fluazifop was detected showing the herbicidally active Fluazifop-P-butyl and R-fluazifop were configurationally stable.
Investigating the phytotoxicity of the graminicide Fluazifop-P-butyl against native UK wildflower species
Pest Manag Sci 2012 Mar;68(3):412-21.PMID:21972119DOI:10.1002/ps.2282.
Background: The selective graminicide Fluazifop-P-butyl is used for the control of grass weeds in dicotyledonous crops, and commonly applied in amenity areas to reduce grass productivity and promote wildflower establishment. However, evidence suggests that Fluazifop-P-butyl might also have phytotoxic effects on some non-target plants. This study investigates the effects of Fluazifop-P-butyl on the emergence, phytotoxicity and above-ground biomass of nine perennial wildflower species and two grass species, following pre- and post-emergent applications at half, full and double label rates in a series of glasshouse experiments. Results: While pre- and post-emergent applications of Fluazifop-P-butyl caused reductions in seedling emergence and increased phytotoxicity on native wildflower and grass species, these effects were temporary for the majority of wildflower species tested, and generally only occurred at the double application rate. No differences in biomass were observed at any of the rates, suggesting good selectivity and no long-term effects of Fluazifop-P-butyl application on the wildflower species from either pre-emergent or post-emergent applications. Conclusion: These results have direct relevance to the management of amenity areas for biodiversity, as they confirm the suitability of these wildflower species for inclusion in seed mixtures where Fluazifop-P-butyl is to be applied to control grass productivity.
Herbicides diuron and Fluazifop-P-butyl affect avoidance response and multixenobiotic resistance activity in earthworm Eisenia andrei
Chemosphere 2018 Nov;210:110-119.PMID:29986216DOI:10.1016/j.chemosphere.2018.07.008.
The usage of pesticides has been steadily increasing over the last decades, and among them herbicides are the most commonly used ones. Despite their main mode of action targeting plant organisms, they can also have adverse effects on non-target animal organisms. In soil ecosystems, earthworms play an important role due to their positive impacts on the soil functioning and they represent good model organisms in soil ecotoxicology. The aim of the present study was to assess the effects of two herbicides on several endpoints at different levels of biological organization in the earthworm Eisenia andrei. Diuron and Fluazifop-P-butyl were selected for the investigation and their lethal concentrations were determined: LC50 48 h: 89.087 μg/cm2 for diuron and 6.167 μg/cm2 for Fluazifop-P-butyl. Furthermore, measurements of enzymatic biomarkers (catalase (CAT), acetylcholinesterase (AChE), carboxylesterase (CES) and glutathione S-transferase (GST)), multixenobiotic resistance (MXR) activity and gene expression of antioxidative enzymes (only for Fluazifop-P-butyl) were conducted. Enzymatic biomarker responses showed no significant differences compared to the control after the exposure to the investigated herbicides, whereas the MXR activity was significantly inhibited. The gene expression level of superoxide dismutase (sod) and glutathione S-transferase (gst) after Fluazifop-P-butyl exposure showed a significant increase. Finally, avoidance behavior in soil was assessed and it was determined that both herbicides caused significant avoidance response. The obtained results show that both investigated herbicides significantly affect earthworms on different levels of biological organization. This emphasizes the importance of comprehensive ecotoxicological assessment of herbicide effects on non-target organisms at all organizational levels.