Fludioxonil
(Synonyms: 咯菌腈) 目录号 : GC47361
A fungicide
Cas No.:131341-86-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fludioxonil is a phenylpyrrole fungicide.1 It inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC50s = 0.06-0.38 mg/L).2 Fludioxonil also inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385 in a concentration-dependent manner.1,3 It is an estrogen receptor α (ERα) agonist (EC50 = 3.7 μM in a yeast reporter assay) that induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro.4
1.Kim, J.H., Campbell, B.C., Mahoney, N., et al.Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress responseLett. Appl. Microbiol.45(2)134-141(2007) 2.Li, X., FernÁndez-OrtuÑo, D., Grabke, A., et al.Resistance to fludioxonil in Botrytis cinerea isolates from blackberry and strawberryPhytopathology104(7)724-732(2014) 3.Ochiai, N., Fujimura, M., Oshima, M., et al.Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicansBiosci. Biotechnol. Biochem.66(10)2209-2215(2002) 4.Teng, Y., Manavalan, T.T., Hu, C., et al.Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cellsToxicol. Sci.131(1)71-83(2013)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.029 mL | 20.145 mL | 40.2901 mL |
| 5 mM | 0.8058 mL | 4.029 mL | 8.058 mL |
| 10 mM | 0.4029 mL | 2.0145 mL | 4.029 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。