Fluoroethylnormemantine hydrochloride
目录号 : GC69119Fluoroethylnormemantine hydrochloride 是 Memantine 的衍生物，是 N-甲基-D-天冬氨酸 (NMDA) 受体的拮抗剂。[18F]-Fluoroethylnormemantine hydrochloride 可用作正电子发射断层扫描 (PET) 示踪剂。Fluoroethylnormemantine hydrochloride 具有抗遗忘、神经保护、抗抑郁样和减轻恐惧的作用。
Cas No.:1639210-25-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fluoroetlnormemantine drochloride, a derivative of Memantine, is an antagonist of the N-metl-D-aspartate (NMDA) receptor. [18F]-Fluoroetlnormemantine drochloride can be used as a positron emission tomograp (PET) tracer. Fluoroetlnormemantine drochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].
Fluoroetlnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1].
Fluoroetlnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroetlnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].
| Animal Model: | Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1] |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | I.p. 30 minutes before the behavioral tests |
| Result: | Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit. |
[1]. Couly S, et, al. Anti-Amnesic and Neuroprotective Effects of Fluoroetlnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157.
[2]. Chen BK, et, al. Fluoroetlnormemantine, a novel derivative of memantine, facilitates extinction learning without sensorimotor deficits. Int J Neuropsychopharmacol. 2021 Feb 25;pyab007.
[3]. Chen BK, et, al. Fluoroetlnormemantine, a novel NMDA receptor antagonist, for the prevention and treatment of stress-induced maladaptive behavior. Biological Psychiatry. 2021 May 9.
| Cas No. | 1639210-25-5 | SDF | Download SDF |
| 分子式 | C12H21ClFN | 分子量 | 233.75 |
| 溶解度 | DMSO : ≥ 100 mg/mL (427.81 mM) | 储存条件 | Store at -20°C, away from moisture |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.2781 mL | 21.3904 mL | 42.7807 mL |
| 5 mM | 0.8556 mL | 4.2781 mL | 8.5561 mL |
| 10 mM | 0.4278 mL | 2.139 mL | 4.2781 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。