Fluridone
(Synonyms: 氟啶酮) 目录号 : GC49125
Fluridone是脱落酸（ABA）生物合成的有效抑制剂，可用作除草剂，特别是用于消除水库和灌溉渠道中的水生植物。
Cas No.:59756-60-4
Sample solution is provided at 25 µL, 10mM.
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Fluridone is a potent inhibitor of abscisic acid (ABA) biosynthesis and is used as a herbicide, particularly for the elimination of aquatic plants in reservoirs and irrigation channels[1].
Treatment of kiwifruit wound tissue with Fluridone inhibited the levels of transcription factors AchnMYB41, AchnMYB107 and AchnMYC2 and reduced primary alcohol formation[1]. Fluridone (50 and 100μM) induced the accumulation of phytoene and reduced β-carotene levels in T. aestivum seedlings grown in the dark[2].
Fluridone reduces the hatching success rate of medaka embryos in a dose-dependent manner, with the maximum effective concentration for hatching success being 2.3mg/L. Male and female medaka larvae were acutely exposed to Fluridone for 6 hours. Fluridone at concentrations of 4.2mg/L or higher caused the larvae to become lethargic and exhibit abnormal swimming behavior[3]. Fluridone is acutely toxic to invertebrates and fish, with median lethal concentrations (LC50) of 4.3 ± 3.7 and 10.4 ± 3.9mg/L, respectively[4].
References:
[1] Wei X, Mao L, Wei X, Xia M, Xu C. MYB41, MYB107, and MYC2 promote ABA-mediated primary fatty alcohol accumulation via activation of AchnFAR in wound suberization in kiwifruit. Hortic Res. 2020 Jun 1;7(1):86.
[2] Bartels P G, Watson C W. Inhibition of carotenoid synthesis by fluridone and norflurazon[J]. Weed Science, 1978, 26(2): 198-203.
[3] Jin J, Kurobe T, Hammock B G, et al. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)[J]. Science of the Total Environment, 2020, 700: 134495.
[4] Hamelink J L, Buckler D R, Mayer F L, et al. Toxicity of fluridone to aquatic invertebrates and fish[J]. Environmental Toxicology and Chemistry: An International Journal, 1986, 5(1): 87-94.
Fluridone是脱落酸（ABA）生物合成的有效抑制剂，可用作除草剂，特别是用于消除水库和灌溉渠道中的水生植物[1]。
使用Fluridone处理猕猴桃伤口组织可抑制转录因子AchnMYB41、AchnMYB107和AchnMYC2的水平，减少伯醇形成[1]。Fluridone（50和100μM）可诱导在黑暗中生长的T. aestivum 幼苗中八氢番茄红素的积累，减少β-胡萝卜素水平[2]。
Fluridone以剂量依赖性方式降低青鳉胚胎孵化成功率，孵化成功的半数最大有效浓度为2.3mg/L。雄性和雌性青鳉幼虫急性暴露于Fluridone 6小时，4.2mg/L或更高浓度的Fluridone使幼鱼变得嗜睡并表现出异常的游泳行为[3]。Fluridone对无脊椎动物和鱼类具有急性毒性，半数致死浓度 (LC50) 分别为4.3 ± 3.7和10.4±3.9mg/L[4]。
| Cell experiment [1]: | |
Cell lines | S. capricornutum cells |
Preparation Method | The concentrations of total colored carotenoid pigments were determined for each Fluridone treatment by a standard spectrophotometric method. |
Reaction Conditions | 1.65, 3.3 and 33μg/L, 48h |
Applications | Concentrations of colored carotenoid pigments in S. capricornutum cells were reduced after 48h exposure, relative to the no Fluridone treatments, to concentrations of Fluridone greater than 3.3μg/L. |
| Animal experiment [2]: | |
Animal models | Male and female Medaka embryos ( < 6h post fertilization） |
Preparation Method | Then 50 healthy embryos were placed in each 50mL Pyrex beakers containing 15mL of Fluridone solution for batch exposure (one beaker per concentration). A 50% (7.5mL) solution was changed at 2 d post exposure (dpe). At 4 dpe, embryos were separated by sex based on the presence of leucophores on males and then transferred into 96-well plates. Each well had one embryo placed inside and contained 200mL of experimental solution. A total of 16 embryos for each sex were used per treatment. More than 80% of the volume in each well was changed every 2 days for the remainder of the experiment. Each embryo was observed daily using a dissecting microscope and recorded for mortality, hatching success, and signs of abnormal development. The experiment was terminated at 14 dpe (4 days in beaker, 10 days in plate), and fish embryos that failed to hatch were counted. |
Dosage form | 0, 0.03, 0.5, 1, 2 and 4mg/L, 14 days |
Applications | Male and female Medaka embryos were exposed to Fluridone for 14 days and showed reduced hatching success in a dose dependent manner. The half maximal effective concentration for the hatching success was 2.3mg/L. |
References: [1] Gala W R, Giesy J P. Using the carotenoid biosynthesis inhibiting herbicide, Fluridone, to investigate the ability of carotenoid pigments to protect algae from the photo-induced toxicity of anthracene[J]. Aquatic toxicology, 1993, 27(1-2): 61-70. [2] Jin J, Kurobe T, Hammock B G, et al. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)[J]. Science of the Total Environment, 2020, 700: 134495. | |
| Cas No. | 59756-60-4 | SDF | |
| 别名 | 氟啶酮 | ||
| Canonical SMILES | O=C1C(C2=CC=CC=C2)=CN(C)C=C1C3=CC(C(F)(F)F)=CC=C3 | ||
| 分子式 | C19H14F3NO | 分子量 | 329.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 20 mg/ml | 储存条件 | Store at -20°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0367 mL | 15.1837 mL | 30.3674 mL |
| 5 mM | 0.6073 mL | 3.0367 mL | 6.0735 mL |
| 10 mM | 0.3037 mL | 1.5184 mL | 3.0367 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet