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Fsh receptor-binding inhibitor fragment(bi-10)

目录号 : GC72225

Fsh receptor-binding inhibitor fragment(bi-10)是一种强效的FSH拮抗剂。

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

Cas No.:163973-98-6

规格 价格 库存 购买数量
1 mg
¥495.00
现货
5 mg
¥1,170.00
现货
10 mg
¥1,890.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries.

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; Intramuscularly injection; once a day for five consecutive days) with high dose (30 mg/kg to 40 mg/kg) can suppress ovarian and follicular development, and attenuate expression levels of ERβ and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production[1].

References:
[1]. Gong Zhuandi, et al. FSH receptor binding inhibitor restrains follicular development and possibly attenuates carcinogenesis of ovarian cancer through down-regulating expression levels of FSHR and ERβ in normal ovarian tissues. Gene. 2018 Aug 20;668:174-181.

化学性质

Cas No. 163973-98-6 SDF
分子式 C42H67N13O19 分子量 1058.06
溶解度 DMSO : 100 mg/mL (94.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) 储存条件 Sealed storage, away from moisture
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1 mg 5 mg 10 mg
1 mM 0.9451 mL 4.7256 mL 9.4513 mL
5 mM 0.189 mL 0.9451 mL 1.8903 mL
10 mM 0.0945 mL 0.4726 mL 0.9451 mL
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