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Fucosterol Sale

(Synonyms: 岩皂甾醇,24-ethylidene Cholesterol) 目录号 : GC10456

A natural phytosterol with diverse biological activities

Fucosterol Chemical Structure

Cas No.:17605-67-3

规格 价格 库存 购买数量
5 mg
¥891.00
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10 mg
¥1,512.00
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20 mg
¥2,574.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Fucosterol is a plant sterol found in algae that has diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others.[1] It decreases markers of oxidative damage and increases antioxidative enzyme activity in vitro.[2] It reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages.[3] In HEK293, MCF-7, and SiHa cells, fucosterol decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively).[4] It also has anticancer activity in HL-60 leukemia cells, where it inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM.[5] In a streptozotocin rat model of diabetes, it decreases serum glucose concentrations when administered at 30 mg/kg.[6]

Reference:
[1]. Abdul, Q.A., Choi, R.J., Jung, H.A., et al. Health benefit of fucosterol from marine algae: A review J. Sci. Food Agric. 96(6), 1856-1866 (2015).
[2]. Lee, S., Lee, Y.S., Jung, S.H., et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa Arch. Pharm. Res. 26(9), 719-722 (2003).
[3]. Yoo, M.S., Shin, J.S., Choi, H.E., et al. Fucosterol isolated from Undaria pinnatifida inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines via the inactivation of nuclear factor-κB and p38 mitogen-activated protein kinase in RAW264.7 macrophages Food Chem. 135(3), 967-975 (2012).
[4]. Caamal-Fuentes, E., Moo-Puc, R., Freile-Pelegrin, Y., et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata Pharm. Biol. 52(10), 1244-1248 (2014).
[5]. Yi, Y.B., Ji, C.F., and Yue, L. Study on human promyelocytic leukemia HL-60 cells apoptosis induced by fucosterol Biomed. Mater. Eng. 24(1), 845-851 (2014).
[6]. Lee, Y.S., Shin, K.H., Kim, B.K., et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa Arch. Pharm. Res. 27(11), 1120-1122 (2004).

Chemical Properties

Cas No. 17605-67-3 SDF
别名 岩皂甾醇,24-ethylidene Cholesterol
化学名 (3β,24E)-stigmasta-5,24(28)-dien-3-ol
Canonical SMILES C/C=C(C(C)C)\CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式 C29H48O 分子量 412.7
溶解度 24-ethylidene Cholesterol 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1153 mL 24.2307 mL
5 mM 0.4846 mL 2.4231 mL 4.8461 mL
10 mM 0.2423 mL 1.2115 mL 2.4231 mL
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