Fucosterol
(Synonyms: 岩皂甾醇,24-ethylidene Cholesterol) 目录号 : GC10456A natural phytosterol with diverse biological activities
Cas No.:17605-67-3
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fucosterol is a plant sterol found in algae that has diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others.[1] It decreases markers of oxidative damage and increases antioxidative enzyme activity in vitro.[2] It reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages.[3] In HEK293, MCF-7, and SiHa cells, fucosterol decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively).[4] It also has anticancer activity in HL-60 leukemia cells, where it inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM.[5] In a streptozotocin rat model of diabetes, it decreases serum glucose concentrations when administered at 30 mg/kg.[6]
Reference:
[1]. Abdul, Q.A., Choi, R.J., Jung, H.A., et al. Health benefit of fucosterol from marine algae: A review J. Sci. Food Agric. 96(6), 1856-1866 (2015).
[2]. Lee, S., Lee, Y.S., Jung, S.H., et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa Arch. Pharm. Res. 26(9), 719-722 (2003).
[3]. Yoo, M.S., Shin, J.S., Choi, H.E., et al. Fucosterol isolated from Undaria pinnatifida inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines via the inactivation of nuclear factor-κB and p38 mitogen-activated protein kinase in RAW264.7 macrophages Food Chem. 135(3), 967-975 (2012).
[4]. Caamal-Fuentes, E., Moo-Puc, R., Freile-Pelegrin, Y., et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata Pharm. Biol. 52(10), 1244-1248 (2014).
[5]. Yi, Y.B., Ji, C.F., and Yue, L. Study on human promyelocytic leukemia HL-60 cells apoptosis induced by fucosterol Biomed. Mater. Eng. 24(1), 845-851 (2014).
[6]. Lee, Y.S., Shin, K.H., Kim, B.K., et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa Arch. Pharm. Res. 27(11), 1120-1122 (2004).
Cas No. | 17605-67-3 | SDF | |
别名 | 岩皂甾醇,24-ethylidene Cholesterol | ||
化学名 | (3β,24E)-stigmasta-5,24(28)-dien-3-ol | ||
Canonical SMILES | C/C=C(C(C)C)\CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C | ||
分子式 | C29H48O | 分子量 | 412.7 |
溶解度 | 24-ethylidene Cholesterol | 储存条件 | 4°C, protect from light |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.4231 mL | 12.1153 mL | 24.2307 mL |
5 mM | 0.4846 mL | 2.4231 mL | 4.8461 mL |
10 mM | 0.2423 mL | 1.2115 mL | 2.4231 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。