Fumonisin B1-13C34

Fumonisin B₁-¹³C₃₄ (FB₁-¹³C₃₄) is intended for use as an internal standard for the quantification of FB₁ by GC- or LC-MS. FB₁ is a mycotoxin that has been found in F. moniliforme.¹ It inhibits ceramide synthase (IC₅₀ = 0.1 µM for the rat liver enzyme).² FB₁ induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively.³ It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days.⁴ It has been detected in corn and corn-based foods and livestock feeds.⁵

1.Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al.Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliformeAppl. Environ. Microbiol.54(7)1806-1811(1988) 2.Wang, E., Norred, W.P., Bacon, C.W., et al.Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliformeJ. Biol. Chem.266(22)14486-14490(1991) 3.Ciacci-Zanella, J.R., and Jones, C.Fumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activationFood Chem. Toxicol.37(7)703-712(1999) 4.Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al.Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assaysFood Chem. Toxicol.31(6)407-414(1993) 5.Bullerman, L.B.Occurrence of Fusarium and fumonisins on food grains and in foodsFumonisins in food27-38(1996)