Fumonisin B2-13C34

Fumonisin B₂-¹³C₃₄ (FB₂-¹³C₃₄) is intended for use as an internal standard for the quantification of FB₂ by GC- or LC-MS. FB₂ is a mycotoxin that has been found in F. moniliforme.¹ It is cytotoxic against a panel of seven rat hepatoma cell lines (IC₅₀s = 3-50 µg/ml), as well as MDCK cells (IC₅₀ = 2 µg/ml).² FB₂ (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.³ FB₂ has been detected in corn and corn-based foods and livestock feeds.⁴

1.Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al.Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliformeAppl. Environ. Microbiol.54(7)1806-1811(1988) 2.Shier, W.T., Abbas, H.K., and Mirocha, C.J.Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cellsMycopathologia116(2)97-104(1991) 3.Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al.Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assaysFood Chem. Toxicol.31(6)407-414(1993) 4.Bullerman, L.B.Occurrence of Fusarium and fumonisins on food grains and in foodsFumonisins in food27-38(1996)