Furazolidone
(Synonyms: 呋喃唑酮) 目录号 : GC32138
A nitrofuran antiprotozoal and antibacterial agent
Cas No.:67-45-8
Sample solution is provided at 25 µL, 10mM.
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Furazolidone is a nitrofuran antiprotozoal agent and antibacterial agent.1,2,3 It is active against G. lamblia trophozoites (IC50 = 2.9 ?M), as well as metronidazole-susceptible and -resistant T. vaginalis clinical isolates with minimum lethal concentration (MLC) values of less than 3.1 ?g/ml.1,2 Furazolidone is also active against clinical isolates of Salmonella, Shigella, E. coli, and V. parahaemolyticus (MICs = ≤0.5-4 ?g/ml).3 In vivo, furazolidone (50 mg/kg per day) reduces splenic and hepatic parasite burden in a golden hamster model of L. chagasi infection.4 Formulations containing furazolidone have been used in the treatment of bacterial and protozoal infections.
1.Campanati, L., and Monteiro-Leal, L.H.The effects of the antiprotozoal drugs metronidazole and furazolidone on trophozoites of Giardia lamblia (P1 strain)Parasitol Res.88(1)80-85(2002) 2.Narcisi, E.M., and Secor, W.E.In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalisAntimicrob. Agents and Chemother.40(5)1121-1125(1996) 3.Carlson, J.R., Thornton, S.A., Dupont, H.L., et al.Comparative in vitro activities of ten antimicrobial agents against bacterial enteropathogensAntimicrob. Agents Chemother.24(4)509-513(1983) 4.Tempone, A.G., Mortara, R.A., de Andrade, H.F., Jr., et al.Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasisInt. J. Antimicrob. Agents36(2)159-163(2010)
| Cas No. | 67-45-8 | SDF | |
| 别名 | 呋喃唑酮 | ||
| Canonical SMILES | O=C1OCCN1/N=C/C2=CC=C([N+]([O-])=O)O2 | ||
| 分子式 | C8H7N3O5 | 分子量 | 225.16 |
| 溶解度 | DMSO : 10 mg/mL (44.41 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4413 mL | 22.2064 mL | 44.4129 mL |
| 5 mM | 0.8883 mL | 4.4413 mL | 8.8826 mL |
| 10 mM | 0.4441 mL | 2.2206 mL | 4.4413 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet