Fustin
(Synonyms: 黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 目录号 : GC52047
A flavanone with diverse biological activities
Cas No.:20725-03-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fustin is a polyketide synthase-derived flavanone that has been found in R. verniciflua and has diverse biological activities.1,2,3,4 It enhances epigallocatechin-3-O-gallate-induced decreases in the viability of U266 multiple myeloma cells when used at concentrations of 5 and 10 µM.2 Fustin (50 and 100 mg/kg) inhibits increases in blood glucose levels, as well as serum total cholesterol, triglyceride, and malondialdehyde (MDA) levels, in a mouse model of diabetes induced by streptozotocin .3 It prevents decreases in contextual- and tone fear conditioning freezing time, indicating a reversal of memory deficits, induced by amyloid-β (1-42) (Aβ42) in mice when administered at a dose of 100 mg/kg.4
1.MarÍn, L., GutiÉrrez-Del-RÍo, I., Villar, C.J., et al.De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activityMicrob. Biotechnol.14(5)2009-2024(2021) 2.Kumazoe, M., Fujimura, Y., Yoshitomi, R., et al.Fustin, a flavanonol, synergically potentiates the anticancer effect of green tea catechin epigallocatechin-3-O-gallate with activation of the eNOS/cGMP axisJ. Agric. Food Chem.70(11)3458-3466(2022) 3.Gilani, S.J., Bin-Jumah, M.N., Al-Abbasi, F.A., et al.Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changesSaudi J. Biol. Sci.28(12)6963-6971(2021) 4.Jin, C.-H., Shin, E.-J., Park, J.-B., et al.Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairmentJ. Neurosci. Res.87(16)3658-3670(2009)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4686 mL | 17.343 mL | 34.6861 mL |
| 5 mM | 0.6937 mL | 3.4686 mL | 6.9372 mL |
| 10 mM | 0.3469 mL | 1.7343 mL | 3.4686 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。