Z-Phe-Phe-Phe-OH

Z-Phe-Phe-Phe-OH is a tripeptide that can act as a membrane fusion inhibitor, interacting with the cell membrane or viral envelope, interfering with the fusion process of the lipid bilayer, thereby preventing the virus from entering the host cell or inhibiting cell-to-cell fusion^{[1, 2]}. Z-Phe-Phe-Phe-OH is composed of three phenylalanine (Phe) residues connected in sequence by peptide bonds and has a benzyloxycarbonyl (Z-) protecting group at the N-terminus. Phenylalanine is an aromatic amino acid with a benzyl ring in its side chain, which makes it highly hydrophobic and rigid^[3]. The introduction of the benzyloxycarbonyl protecting group provides additional stability to the tripeptide, making it less likely to degrade during the experiment^[4]. The molecular formula of this product is C₃₅H₃₅N₃O₆ and the molecular weight is 593.68.

References:
[1] Zheng C, Zhong Q, Song W, et al. Membrane‐Fusion‐Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy[J]. Advanced Materials, 2023, 35(14): 2206989.
[2] Kong H, Zheng C, Yi K, et al. An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo[J]. Nature Communications, 2024, 15(1): 4267.
[3] Das T, Häring M, Haldar D, et al. Phenylalanine and derivatives as versatile low-molecular-weight gelators: Design, structure and tailored function[J]. Biomaterials science, 2018, 6(1): 38-59.
[4] Bochet C G. Photolabile protecting groups and linkers[J]. Journal of the Chemical Society, Perkin Transactions 1, 2002 (2): 125-142.

Z-Phe-Phe-Phe-OH是一种三肽，可作为一种膜融合抑制剂，与细胞膜或病毒包膜相互作用，干扰脂质双层的融合过程，从而阻止病毒进入宿主细胞或抑制细胞间的融合^{[1, 2]}。Z-Phe-Phe-Phe-OH是由三个苯丙氨酸（Phe）残基通过肽键依次连接而成，并在N-端具有苄氧羰基（Z-）保护基团。苯丙氨酸作为一种芳香族氨基酸，因其侧链中含有苯环，使其具有较强的疏水性和刚性^[3]。苄氧羰基保护基的引入为三肽提供了额外的稳定性，使其在实验过程中不易降解^[4]。本产品的分子式为C₃₅H₃₅N₃O₆，分子量为593.68。