GAD1 iso1 Human
目录号 : GP21650Glutamate Decarboxylase 1 Isoform-1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 80% as determined by SDS-PAGE. | Source | E.coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Glutamate Decarboxylase 1 (Brain; 67kDa); GlutamateDecarboxylase 67 KDa Isoform; 67 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15;GAD-67; CPSQ1; SCP; GAD; Glutamate Decarboxylase 1 (Brain; 67kD); GlutamateDecarboxylase 1; EC 4.1.1; GAD67; Glutamate decarboxylase 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMASSTPS SSATSSNAGA DPNTTNLRPT TYDTWCGVAH GCTRKLGLKICGFLQRTNSL EEKSRLVSAF KERQSSKNLL SCENSDRDAR FRRTETDFSN LFARDLLPAK NGEEQTVQFLLEVVDILLNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLELSDHPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSTGLDI IGLAGEWLTSTANTNMFTYE IAPVFVLMEQ ITLKKMREIV GWSSKDGDGI FSPGGAISNM YSIMAARYKY FPEVKTKGMAAVPKLVLFTS EQSHYSIKKA GAALGFGTDN VILIKCNERG KIIPADFEAK ILEAKQKGYVPFYVNATAGT TVYGAFDPIQ EIADICEKYN LWLHVDAAWG GGLLMSRKHRHKLNGIERAN SVTWNPHKMM GVLLQCSAIL VKEKGILQGC NQMCAGYLFQ PDKQYDVSYD TGDKAIQCGRHVDIFKFWLM WKAKGTVGFE NQINKCLELA EYLYAKIKNR EEFEMVFNGE PEHTNVCFWYIPQSLRGVPD SPQRREKLHKVAPKIKALMM ESGTTMVGYQ PQGDKANFFR MVISNPAATQ SDIDFLIEEI ERLGQDL. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | GAD1 iso1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. | ||
Glutamate Decarboxylase 1 Isoform-1, also known as GAD1 iso1 belongs tothe group II decarboxylase family. GAD1 iso1 encodes one of several forms ofglutamic acid decarboxylase, and is identified as a major autoantigen ininsulin-dependent diabetes. GAD1 iso1 is in charge for catalyzing theproduction of gamma-aminobutyric acid from L-glutamic acid. In addition, apathogenic function for GAD1 iso1 has been shown in the human pancreas while ithas been identified as an autoantigen & an autoreactive T cell target ininsulin-dependent diabetes. GAD1 iso1 play a role in the stiff man syndrome. Ithas been shown that deficiency in this enzyme has led to pyridoxine dependencywith seizures.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.