Galanin (rat, mouse) (trifluoroacetate salt)
(Synonyms: GAL (rat, mouse)) 目录号 : GC43724A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.[3][4] Galanin (5 μg, i.c.v.) also inhibits acetylcholine release induced by scopolamine in the ventral hippocampus of freely moving rats. [5]
Reference:
[1]. Branchek, T.A., Smith, K.E., Gerald, C., et al. Galanin receptor subtypes. Trends Pharamacol. Sci. 21(3), 109-117 (2000).
[2]. Gu, Z.F., Pradhan, T.K., Coy, D.H., et al. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: Identification of a novel galanin receptor subtype. J. Pharmacol. Exp. Ther. 272(1), 371-378 (1995).
[3]. Crawley, J.N., Austin, M.C., Fiske, S.M., et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10(11), 3695-3700 (1990).
[4]. Yang, Y., Zhang, Y., Li, X.H., et al. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain. Neurosci. Res. 97, 20-25 (2015).
[5]. Taber, M.T., and Crawley, J.N. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus. Psychobiol. 27(1), 57-62 (1999).
| Cas No. | SDF | ||
| 别名 | GAL (rat, mouse) | ||
| 化学名 | glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-histidylglycyl-L-leucyl-L-threoninamide, 2,2,2-trifluoroacetate | ||
| Canonical SMILES | NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC(CN[H])=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)C)=O)=O)CC(O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC(O)=O)=O)=O)CC8=CN=CN8)=O)=O)=O)=O.OC(C(F)(F)F)=O | ||
| 分子式 | C141H211N43O41•XCF3COOH | 分子量 | 3164.4 |
| 溶解度 | 1mg/mL in water | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.316 mL | 1.5801 mL | 3.1602 mL |
| 5 mM | 0.0632 mL | 0.316 mL | 0.632 mL |
| 10 mM | 0.0316 mL | 0.158 mL | 0.316 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet