Home>>Signaling Pathways>> Microbiology & Virology>> Bacterial>>Gamithromycin (ML-1709460)

Gamithromycin (ML-1709460) Sale

(Synonyms: 加米霉素; ML-1709460) 目录号 : GC32112

An antibiotic

Gamithromycin (ML-1709460) Chemical Structure

Cas No.:145435-72-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥897.00
现货
5mg
¥560.00
现货
10mg
¥816.00
现货
25mg
¥1,534.00
现货
50mg
¥2,225.00
现货
100mg
¥3,227.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

Description

Gamithromycin is an antibiotic that is active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 μg/ml, respectively).1 It reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg.2 Formulations containing gamithromycin have been used to treat bovine respiratory diseases.3

1.Berghaus, L.J., Giguère, S., Sturgill, T.L., et al.Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foalsJ. Vet. Pharmacol. Ther.35(1)59-66(2012) 2.Forbes, A.B., Ramage, C., Sales, J., et al.Determination of the duration of antibacterial efficacy following administration of gamithromycin using a bovine Mannheimia haemolytica challenge modelAntimicrob. Agents Chemother.55(2)831-835(2011) 3.Capik, S.F., White, B.J., Lubbers, B.V., et al.Comparison of the diagnostic performance of bacterial culture of nasopharyngeal swab and bronchoalveolar lavage fluid samples obtained from calves with bovine respiratory diseaseAm. J. Vet. Res.78(3)350-358(2017)

实验参考方法

Cell experiment:

Minimum inhibitory concentrations (MICs) for gamithromycin, tylosin and tilmicosin against MmmSC strains B237 and Tan8 are determined using a macrodilution technique. Equal volumes of MmmSC culture in logarithmic phase are added to each antimicrobial dilution to give an inoculum size of 107 cfu/mL, i.e. the intending initial titre for subsequent time-kill assays, in a volume of 4 mL. Cultures are incubated for 24 h at 37°C. At 0 and 24 h time points, samples are removed and serially diluted 10-fold down to 10-5. Aliquots (10 μL) of each dilution are transferred to solid medium; after incubation at 37°C in a humidified atmosphere of 5% carbon dioxide in air for at least 4 days, colonies are counted from the dilution that yields between 30 and 300 colonies per plate. Counts are converted into cfu/mL and MIC is defined as the lowest concentration of antimicrobial that prevents an increase in cfu/mL over 24 h[1].

Animal experiment:

Foals with ultrasonographic evidence of pulmonary abscesses are randomly assigned in 3 treatment groups: (1)gamithromycin at a dose of 6.0 mg/kg body weight is administered in the semimembranosus/semitendinosus muscles once a week (GAM; n=40); (2) azithromycin at a dose of 10 mg/kg PO once daily in combination with rifampin at a dose of 10 mg/kg PO once daily (AZM-RIF; n=40); and (3) no antimicrobial treatment (controls; n=41). All the foals in each treatment group also receive acetylcysteine at a dose of 10 mg/kg PO a day to provide the same daily manipulation of the foals in each group[2].

References:

[1]. Mitchell JD, et al. In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony. Vet J. 2013 Sep;197(3):806-11.
[2]. F. Hildebrand, et al. Efficacy of Gamithromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia. J Vet Intern Med. 2015 Jan-Feb; 29(1): 333–338.

化学性质

Cas No. 145435-72-9 SDF
别名 加米霉素; ML-1709460
Canonical SMILES O[C@H]([C@H](C[C@@H](C)O1)N(C)C)[C@]1([H])O[C@@H]2[C@H]([C@@H]([C@H](C(O[C@@H]([C@@](C)(O)[C@H](O)[C@@H](C)CN(CCC)[C@H](C)C[C@]2(O)C)CC)=O)C)O[C@@]3([H])C[C@](C)([C@@H](O)[C@H](C)O3)OC)C
分子式 C40H76N2O12 分子量 777.04
溶解度 DMSO : 160 mg/mL (205.91 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.2869 mL 6.4347 mL 12.8694 mL
5 mM 0.2574 mL 1.2869 mL 2.5739 mL
10 mM 0.1287 mL 0.6435 mL 1.2869 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置

产品文档

Quality Control & SDS

View current batch: