Ganglioside GM4 (chicken egg) (ammonium salt)
(Synonyms: Ganglioside G7, Monosialoganglioside GM4) 目录号 : GC52487A sphingolipid
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ganglioside GM4 is a sialic acid-containing glycosphingolipid found primarily in the brain of mammals, particularly in human myelin.1 Ganglioside GM4 is also found on epithelial cells in the intestinal tract of the red sea bream where it is an attachment site for Gram-negative Vibrios, the bacteria that causes vibriosis in humans after ingestion of raw or undercooked seafood.2 Ganglioside GM4 species have been found as 11 out of 61 gangliosides detected in an adrenal neuroblastoma tumor.3 Administration of ganglioside GM4 (80 and 160 µg) prevents development of myelin basic protein-induced experimental autoimmune encephalomyelitis (EAE) in guinea pigs.4 This product contains ganglioside GM4 molecular species with primarily 2-hydroxy C22:0, 2-hydroxy C24:0, and 2-hydroxy C23:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1535]
1.Ueno, K., Ando, s., and Yu, R.K.Gangliosides of human, cat, and rabbit spinal cords and cord myelinJ. Lipid Res.19(7)863-871(1978) 2.Chisada, S., Shimizu, K., Kamada, H., et al.Vibrios adhere to epithelial cells in the intestinal tract of red sea bream, Pagrus major, utilizing GM4 as an attachment siteFEMS Microbiol. Lett.341(1)18-26(2013) 3.Robu, A.C., Vukeli?, ?., Schiopu, C., et al.Mass spectrometry of gangliosides in extracranial tumors: Application to adrenal neuroblastomaAnal. Biochem.5091-11(2016) 4.Mullin, B.R., Patrick, D.H., Poore, C.M., et al.Prevention of experimental allergic encephalomyelitis by ganglioside GM4Brain Res.296(1)174-176(1984)
| Cas No. | SDF | Download SDF | |
| 别名 | Ganglioside G7, Monosialoganglioside GM4 | ||
| Canonical SMILES | O[C@H]1[C@@](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)([H])O[C@H](CO)[C@H](O)[C@]1([H])O[C@]2(C(O)=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O2.N | ||
| 分子式 | C57H106N2O17 ? NH3 (for 2-hydroxydocosanoyl) | 分子量 | 1108.5 |
| 溶解度 | Chloroform:Methanol (2:1): Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.9021 mL | 4.5106 mL | 9.0212 mL |
| 5 mM | 0.1804 mL | 0.9021 mL | 1.8042 mL |
| 10 mM | 0.0902 mL | 0.4511 mL | 0.9021 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。