(-)-Isocorypalmine

(–)-Isocorypalmine is an isoquinoline alkaloid and a metabolite of L-tetrahydropalmitine that has been found in Corydalis and has diverse biological activities.^1,2,3,4,5 It binds to human dopamine D_1-5 receptors with K_i values of 6.2, 41.8, 37.3, 77.4, and 9.5 nM, respectively.² (–)-Isocorypalmine inhibits Epstein-Barr virus-early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells (IC₅₀ = 300 mol ratio/32 pmol TPA), which is predictive for anti-tumor activity.³ It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cancer cells (IC₅₀s = 67.32, 47.37, 47.66, and 67.32 μM, respectively).⁴ (–)-Isocorypalmine is active against clinical strains of C. albicans, C. glabratas, C. krusei, C. parapsilosis, and C. neoformans (MICs = 40-320 μg/ml).⁵

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