(-)-Menthol
(Synonyms: L-薄荷醇) 目录号 : GC34951
A monoterpene with diverse biological activities
Cas No.:2216-51-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(–)-Menthol is a monoterpene that has been found in cornmint oil and has diverse biological activities.1 It inhibits acetylcholinesterase (AChE; Ki = 1.25 mM for the bovine enzyme).2 (–)-Menthol (1.6 mM) decreases expression of the genes encoding topoisomerase I, IIα, and Iiβ in, and cell viability of, SNU-5 gastric cancer cells.3 It is active against the plant pathogenic bacteria A. tumefaciens and E. carotovora (MICs = 2.5 and 4 ?g/ml, respectively).4 (–)-Menthol (3-10 mg/kg) reduces acetic acid-induced writhing and increases latency to paw licking in a hot plate test in mice.5
1.Kamatou, G.P., Vermaak, I., Viljoen, A.M., et al.Menthol: A simple monoterpene with remarkable biological propertiesPhytochemistry9615-25(2013) 2.Miyazawa, M., Watanabe, H., and Kameoka, H.Inhibition of acetylcholinesterase activity by monoterpenoids with a p-menthane skeletonJ. Agric. Food Chem.45(3)677-679(1997) 3.Lin, J.P., Lu, H.F., Lee, J.H., et al.(-)-Menthol inhibits DNA topoisomerases I, II α and β and promotes NF-? B expression in human gastric cancer SNU-5 cellsAnticancer Res.25(3B)2069-2074(2005) 4.Rasoul, M.A.A., Marei, G.I.K., and Abdelgaleil, S.A.M.Evaluation of antibacterial properties and biochemical effects of monoterpenes on plant pathogenic bacteriaAfr. J. Microbiol. Res.6(15)3667-3672(2012) 5.Galeotti, N., Di Cesare Mannelli, L., Mazzanti, G., et al.Menthol: A natural analgesic compoundNeurosci. Lett.322(3)145-148(2002)
| Cas No. | 2216-51-5 | SDF | |
| 别名 | L-薄荷醇 | ||
| Canonical SMILES | O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1 | ||
| 分子式 | C10H20O | 分子量 | 156.27 |
| 溶解度 | DMSO: 100 mg/mL (639.92 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.3992 mL | 31.9959 mL | 63.9918 mL |
| 5 mM | 1.2798 mL | 6.3992 mL | 12.7984 mL |
| 10 mM | 0.6399 mL | 3.1996 mL | 6.3992 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。