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[Leu5]-Enkephalin, amide Sale

(Synonyms: Leu-Enkephalin amide) 目录号 : GC35017

[Leu5]-Enkephalin, amide 是一种 δ 阿片受体 (opioid receptor) 激动剂。

[Leu5]-Enkephalin, amide Chemical Structure

Cas No.:60117-24-0

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10mg
¥693.00
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25mg
¥1,260.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist. δ opioid receptor[1]

[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.1 nM[2].

Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].

[1]. Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.

Chemical Properties

Cas No. 60117-24-0 SDF
别名 Leu-Enkephalin amide
分子式 C28H38N6O6 分子量 554.64
溶解度 DMSO : 250 mg/mL (450.74 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.803 mL 9.0149 mL 18.0297 mL
5 mM 0.3606 mL 1.803 mL 3.6059 mL
10 mM 0.1803 mL 0.9015 mL 1.803 mL
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