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3-O-Acetyloleanolic acid Sale

(Synonyms: 齐墩果酸3-乙酸酯) 目录号 : GC35099

A triterpene with diverse biological activities

3-O-Acetyloleanolic acid Chemical Structure

Cas No.:4339-72-4

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5mg
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Sample solution is provided at 25 µL, 10mM.

Description

Oleanolic acid acetate is a triterpene that has been found in the root bark of M. macrophylla and has diverse biological activities.1,2,3,4 It is active against P. gingivalis (MIC = 39 ?g/ml).1 Oleanolic acid acetate (5-50 ?M) induces apoptosis in and reduces viability of HCT116 colon carcinoma cells.2 It induces apoptosis in human umbilical vein endothelial cells (HUVECs) in vitro and inhibits capillary vessel formation in a Matrigel? plug assay in mice.3 Oleanolic acid acetate (2, 10, and 50 mg/kg) reduces the number of skin lesions, epidermal thickness and immune cell infiltration, and serum IgE, IgG2a, and histamine levels in a mouse model of atopic dermatitis.4

1.Kim, N.-C., Desjardins, A.E., Wu, C.D., et al.Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogensJ. Nat. Prod.62(10)1379-1384(1999) 2.Yoo, K.H., Park, J.-H., Cui, E.J., et al.3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cellsPhytother. Res.26(10)1541-1546(2012) 3.Cui, E.-J., Hwang-Bo, J., Park, J.-H., et al.3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cellsBiotechnol. Lett.35(11)1807-1815(2013) 4.Choi, J.K., Oh, H.-M., Lee, S., et al.Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine modelToxicol. Appl. Pharmacol.269(1)72-80(2013)

化学性质

Cas No. 4339-72-4 SDF
别名 齐墩果酸3-乙酸酯
Canonical SMILES C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)C4)CC3)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](OC(C)=O)CC5)C)([H])CC2)C)C
分子式 C32H50O4 分子量 498.74
溶解度 DMF: 0.14mg/mL 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0051 mL 10.0253 mL 20.0505 mL
5 mM 0.401 mL 2.0051 mL 4.0101 mL
10 mM 0.2005 mL 1.0025 mL 2.0051 mL
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