3-O-Acetyloleanolic acid
(Synonyms: 齐墩果酸3-乙酸酯) 目录号 : GC35099A triterpene with diverse biological activities
Cas No.:4339-72-4
Sample solution is provided at 25 µL, 10mM.
Oleanolic acid acetate is a triterpene that has been found in the root bark of M. macrophylla and has diverse biological activities.1,2,3,4 It is active against P. gingivalis (MIC = 39 ?g/ml).1 Oleanolic acid acetate (5-50 ?M) induces apoptosis in and reduces viability of HCT116 colon carcinoma cells.2 It induces apoptosis in human umbilical vein endothelial cells (HUVECs) in vitro and inhibits capillary vessel formation in a Matrigel? plug assay in mice.3 Oleanolic acid acetate (2, 10, and 50 mg/kg) reduces the number of skin lesions, epidermal thickness and immune cell infiltration, and serum IgE, IgG2a, and histamine levels in a mouse model of atopic dermatitis.4
1.Kim, N.-C., Desjardins, A.E., Wu, C.D., et al.Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogensJ. Nat. Prod.62(10)1379-1384(1999) 2.Yoo, K.H., Park, J.-H., Cui, E.J., et al.3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cellsPhytother. Res.26(10)1541-1546(2012) 3.Cui, E.-J., Hwang-Bo, J., Park, J.-H., et al.3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cellsBiotechnol. Lett.35(11)1807-1815(2013) 4.Choi, J.K., Oh, H.-M., Lee, S., et al.Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine modelToxicol. Appl. Pharmacol.269(1)72-80(2013)
Cas No. | 4339-72-4 | SDF | |
别名 | 齐墩果酸3-乙酸酯 | ||
Canonical SMILES | C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)C4)CC3)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](OC(C)=O)CC5)C)([H])CC2)C)C | ||
分子式 | C32H50O4 | 分子量 | 498.74 |
溶解度 | DMF: 0.14mg/mL | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.0051 mL | 10.0253 mL | 20.0505 mL |
5 mM | 0.401 mL | 2.0051 mL | 4.0101 mL |
10 mM | 0.2005 mL | 1.0025 mL | 2.0051 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet