4'-Methoxyresveratrol
(Synonyms: 白藜芦醇-4'-甲醚; 4'-O-Methylresveratrol) 目录号 : GC35137
A stilbene with diverse biological activities
Cas No.:33626-08-3
Sample solution is provided at 25 µL, 10mM.
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4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.1,2,3,4 It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 ?g/ml, respectively).1 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid .2 It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.3 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.4
1.Ryu, S.Y., Choi, S.U., Lee, C.O., et al.Antitumor activity of some phenolic components in plantsArch. Pharm. Res.1742-44(1994) 2.Ko, S.K., Lee, S.M., and Whang, W.K.Anti-platelet aggregation activity of stilbene derivatives from Rheum UndulatumArch. Pharm. Res.22(4)401-403(1999) 3.Kerem, Z., Regev-Shoshani, G., Flaishan, M.A., et al.Resveratrol and two monomethylated stilbenes from Israeli Rumex bucephalophorus and their antioxidant potentialJ. Nat. Prod.66(9)1270-1272(2003) 4.Tran, P.T., Park, D.-H., Kim, O., et al.Desoxyrhapontigenin inhibits RANKL?induced osteoclast formation and prevents inflammation?mediated bone lossInt. J. Mol. Med.42(1)569-578(2018)
| Cas No. | 33626-08-3 | SDF | |
| 别名 | 白藜芦醇-4'-甲醚; 4'-O-Methylresveratrol | ||
| Canonical SMILES | OC1=CC(O)=CC(/C=C/C2=CC=C(OC)C=C2)=C1 | ||
| 分子式 | C15H14O3 | 分子量 | 242.27 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1276 mL | 20.6381 mL | 41.2763 mL |
| 5 mM | 0.8255 mL | 4.1276 mL | 8.2553 mL |
| 10 mM | 0.4128 mL | 2.0638 mL | 4.1276 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet