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A-674563 hydrochloride Sale

目录号 : GC35212

An Akt inhibitor

A-674563 hydrochloride Chemical Structure

Cas No.:2070009-66-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥1,277.00
现货
2mg
¥840.00
现货
5mg
¥1,470.00
现货
10mg
¥2,310.00
现货
50mg
¥6,965.00
现货
100mg
¥10,500.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1).1 It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families.1 A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4 ?M.1 In vivo, 40 mg/kg/day A-674563 in combination with 15 mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model.1

1.Luo, Y., Shoemaker, A.R., Liu, X., et al.Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivoMol. Cancer Ther.4(6)977-968(2005)

Chemical Properties

Cas No. 2070009-66-2 SDF
Canonical SMILES N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(C=C3)NN=C4C)=CN=C2.[H]Cl
分子式 C22H23ClN4O 分子量 394.90
溶解度 H2O:100 mg/mL (253.23 mM; Need ultrasonic); DMSO:62.5 mg/mL (158.27 mM; Need ultrasonic) 储存条件 -20°C, stored under nitrogen
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5323 mL 12.6614 mL 25.3229 mL
5 mM 0.5065 mL 2.5323 mL 5.0646 mL
10 mM 0.2532 mL 1.2661 mL 2.5323 mL
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