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Aldicarb sulfone Sale

(Synonyms: 涕灭威砜) 目录号 : GC35279

A metabolite of aldicarb

Aldicarb sulfone Chemical Structure

Cas No.:1646-88-4

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10mM (in 1mL DMSO)
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100mg
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产品描述

Aldicarb sulfone is a metabolite and degradation product of the carbamate pesticide aldicarb .1 Aldicarb sulfone (100 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development.

1.Huang, S.P., and Van Gundy, S.D.Effects of aldicarb and its sulfoxide and sulfone on the biology of Tylenchulus semipenetransJ. Nematol.10(1)100-106(1978)

Chemical Properties

Cas No. 1646-88-4 SDF
别名 涕灭威砜
Canonical SMILES CC(S(=O)(C)=O)(C)/C=N/OC(NC)=O
分子式 C7H14N2O4S 分子量 222.26
溶解度 DMSO: ≥ 34 mg/mL (152.97 mM) 储存条件 Store at -20°C
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1 mM 4.4992 mL 22.4962 mL 44.9924 mL
5 mM 0.8998 mL 4.4992 mL 8.9985 mL
10 mM 0.4499 mL 2.2496 mL 4.4992 mL
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Research Update

Effects of aldicarb and its sulfoxide and sulfone on the biology of Tylenchulus semipenetrans

J Nematol 1978 Jan;10(1):100-6.PMID:19305820doi

In laboratory testing, egg hatch of Tylenchulus semipenetrans was stimulated at concentrations of 1 and 10 microg/ml aldicarb solution and inhibited at 50 and 100 microg/ml. Aldicarb was more inhibitory to egg hatch than the aldicarb sulfoxide and the Aldicarb sulfone. Inhibition of hatch at the high concentration was associated with delays in the molting processes, lack of larval movement within the egg, and delays in embryonic development. Nematode motility was reduced at 10, 50, and 100 microg/ml of aldicarb and aldicarb sulfoxide solution, and at 50 and 100 microg/ml Aldicarb sulfone. Male development was retarded at 10 microg/nrl and almost completely inhibited at 50 and 100 microg/ml of the three chemicals. In greenhouse tests, female development antl reproduction on roots of citrus seedlings were suppressed by aldicarb at rates of 2.6 microg/ml and completely inhibited at 10.6 microg/ml of soil solution during a 50-day experimental period. Under field conditions, there was little systemic movement of aldicarb into roots located outside treated areas. Aldicarb reduced the nematode larvae and the female adult population in the second year after the second treatment. There were no differences in egg hatch and sex ratio of citrus nematodes between treated and nontreated roots.

Determination of aldicarb, aldicarb sulfoxide and Aldicarb sulfone in some fruits and vegetables using high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

J Chromatogr A 2000 Aug 4;888(1-2):113-20.PMID:10949478DOI:10.1016/s0021-9673(00)00553-7.

An analytical method for the determination of aldicarb, and its two major metabolites, aldicarb sulfoxide and Aldicarb sulfone in fruits and vegetables is described. Briefly the method consisted of the use of a methanolic extraction, liquid-liquid extraction followed by solid-phase extraction clean-up. Afterwards, the final extract is analyzed by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry (LC-APCI-MS). The specific fragment ion corresponding to [M-74]+ and the protonated molecular [M+H]+ ion were used for the unequivocal determination of aldicarb and its two major metabolites. The analytical performance of the proposed method and the results achieved were compared with those obtained using the common analytical method involving LC with post-column fluorescence detection (FL). The limits of detection varied between 0.2 and 1.3 ng but under LC-FL were slightly lower than when using LC-APCI-MS. However both methods permitted one to achieve the desired sensitivity for analyzing aldicarb and its metabolites in vegetables. The method developed in this work was applied to the trace determination of aldicarb and its metabolites in crop and orange extracts.

Kinetics of aqueous base and acid hydrolysis of aldicarb, aldicarb sulfoxide and Aldicarb sulfone

J Environ Sci Health B 1983;18(2):189-206.PMID:6853962DOI:10.1080/03601238309372363.

The kinetics of degradation of aqueous solutions of aldicarb, aldicarb sulfoxide and aldicarb sul fone by base hydrolysis were investigated. Pseudo first order rate constants of 37 micrograms/l solutions were determined at different hydroxide concentrations by acid-base titration. Second order rate constants were calculated, and it was found that Aldicarb sulfone is more sensitive to hydroxide ion concentration than aldicarb sulfoxide which is more sensitive than aldicarb. Temperature effects were determined by measuring the base hydrolysis rate constant for Aldicarb sulfone at 5, 15, 20, 25, 30, and 35 degrees C. An activation energy of 15.2 +/- 0.1 kcal/mole was calculated. Addition of a neutral electrolyte decreased the rate constant for base hydrolysis. Acid catalyzed hydrolysis rate constants were also measured for Aldicarb sulfone, and, as expected, the reaction was much slower. The second order (reaction) rate constant for base hydrolysis of Aldicarb sulfone is 40.3 (+/- 0.5) liter mole-1min-1; for acid catalyzed hydrolysis it is 7.33 (+/- 0.06) X 10(-4) liter mole-1min-1.

Determination of aldicarb, aldicarb sulfoxide and Aldicarb sulfone in tobacco using high-performance liquid chromatography with dual post-column reaction and fluorescence detection

J Chromatogr A 1994 Apr 1;664(2):289-94.PMID:8199709DOI:10.1016/0021-9673(94)87019-5.

A screening method for the determination of aldicarb (AS) and its sulfoxide (ASX) and sulfone (ASN) metabolites in tobacco at low ppm levels is described. Tobacco samples are extracted using methanol with the aid of sonication at ambient conditions. The extract is filtered and then injected into a high-performance liquid chromatograph equipped with a dual post-column reaction system and a fluorescence detector. Chromatographic separation is performed on a C18 column with a mixture of methanol-acetonitrile-water containing 0.1% of triethanolamine as the mobile phase. Triethanolamine is added to improve peak shape of AS residues and to reduce the undesired interaction between residual silanols and interferences, mainly amino acids and other amines. The average recoveries for AS residues spiked in tobacco are higher than 95% for AS, 91% for ASN and 85% for ASX at levels of 0.5-10 ppm (w/w). The detection limit is 0.5 ppm for each of the target compounds.

High pressure chromatography determination of aldicarb, aldicarb sulfoxide, and Aldicarb sulfone in potatoes

J Assoc Off Anal Chem 1981 May;64(3):724-8.PMID:7240079doi

An ion-suppression reverse phase high pressure liquid chromatographic method is described for the determination of aldicarb, aldicarb sulfoxide, and Aldicarb sulfone in potatoes. Samples are extracted with methylene chloride and Na2SO4, evaporated to dryness, and cleaned up using Sep-Pak silica and Sep-Pak-C18 cartridges. The extract can be successfully analyzed by high pressure liquid chromatography on either a mu LiChrosorb RP-18 or mu Bondapak C18 column and quantitated using a variable wavelength ultraviolet detector set at either 220 or 247 nm. The mobile phase is acetonitrile-buffer (4 + 96) and (30 + 70), buffered to pH 7.6 and flowing at 2 mL/min. Recoveries ranged from 80 to 100%. The minimum detectable amount was 37.5 ng, which easily permitted the quantitation of 0.1 ppm Aldicarb sulfone in 75 g sample. The recovery of aldicarb was low because of its rapid enzymatic oxidation to aldicarb sulfoxide and sulfone.