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Alectinib Hydrochloride Sale

(Synonyms: 艾乐替尼盐酸盐; CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) 目录号 : GC35280

Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

Alectinib Hydrochloride Chemical Structure

Cas No.:1256589-74-8

规格 价格 库存 购买数量
2mg
¥245.00
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5mg
¥350.00
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50mg
¥840.00
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100mg
¥1,344.00
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200mg
¥2,184.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

Alectinib inhibits ALK with an IC50 value of 1.9 nmol/L and shows higher selectivity for ALK than for a number of other serine/tyrosine kinases. It also inhibits the ALK gatekeeper mutation L1196M with an IC50 of 1.56 nmol/L. Alectinib is effective with crizotinib-resistant ALK mutations L1196M, F1174L, R1275Q and C1156Y. In the KARPAS-299 (lymphoma), NB-1 (neuroblastoma) and NCI-H2228 (lung cancer) ALK-positive cell lines, alectinib inhibits cell proliferation with IC50 values of 3, 4.5 and 53 nmol/L, respectively[1].

Alectinib dose-dependently inhibits EML4-ALK positive NCI-H2228 xenograft model at doses ranging from 2 to 20 mg/kg p.o., q.d. Significant efficacy is also achieved in the EML4-ALK L1196M-driven tumors[1]. It has antitumor activity against cancers with ALK gene alterations[2].

[1] Song Z, et al. Acta Pharm Sin B. 2015, 5(1):34-7. [2] Kodama T, et al. Cancer Lett. 2014, 351(2):215-21. [3] Ke Yang, et al. Exp Mol Med. 2017, 49(3): e303.

Chemical Properties

Cas No. 1256589-74-8 SDF
别名 艾乐替尼盐酸盐; CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride
Canonical SMILES [H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1
分子式 C30H35ClN4O2 分子量 519.08
溶解度 DMSO: 6 mg/mL (11.56 mM and warming) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9265 mL 9.6324 mL 19.2649 mL
5 mM 0.3853 mL 1.9265 mL 3.853 mL
10 mM 0.1926 mL 0.9632 mL 1.9265 mL
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