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Amylin, amide, rat Sale

(Synonyms: Amylin (rat)) 目录号 : GC35333

Amylin, amide, rat 是一种有效的高亲和力的胰淀素受体 AMY1 和 AMY3 的配体。

Amylin, amide, rat Chemical Structure

Cas No.:124447-81-0

规格 价格 库存 购买数量
500μg
¥1,800.00
现货
1mg
¥2,880.00
现货
5mg
¥10,800.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor. Amylin receptor AMY1 and AMY3[1]

Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. Amylin is a member of the calcitonin (CT) family of peptides, which includes CT itself, the CGRPs comprising two variants (αCGRP and βCGRP), adrenomedullin (AM) and AM2 (intermedin). Amylin is a centrally acting, neuroendocrine hormone synthesized with insulin in the beta cells of pancreatic islets. Amylin regulates glucose homeostasis by inhibiting gastric emptying, inhibiting the release of the counter-regulatory hormone glucagon and inducing meal-ending satiety. Amylin functions as a glucoregulatory and satiety-inducing hormone, which is protective against postprandial spikes in blood glucose and overeating.[1]

[1]. Bower RL, et al. Amylin structure-function relationships and receptor pharmacology: implications for Amylin mimetic drug development. Br J Pharmacol. 2016 Jun;173(12):1883-98.

Chemical Properties

Cas No. 124447-81-0 SDF
别名 Amylin (rat)
分子式 C167H272N52O53S2 分子量 3920.44
溶解度 H2O : 100 mg/mL (25.51 mM; Need ultrasonic); DMSO : 50 mg/mL (12.75 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.2551 mL 1.2754 mL 2.5507 mL
5 mM 0.051 mL 0.2551 mL 0.5101 mL
10 mM 0.0255 mL 0.1275 mL 0.2551 mL
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