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Caesappanin C Sale

目录号 : GC35578

Caesappanin C 是一种来自印度尼西亚 Caesalpinia sappan L. 心材的乙醇提取物的联苯二聚体,在体外显示出对原代成骨细胞的强增殖刺激活性。 Caesappanin C 具有刺激骨形成和再生的潜力。

Caesappanin C Chemical Structure

Cas No.:1913319-59-1

规格 价格 库存 购买数量
1mg 待询 待询
5mg
¥2,268.00
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产品描述

Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration[1].

[1]. Subehan, et al. Phytochemical investigation of the active constituents from Caesalpinia sappan on stimulation of osteoblastic cells. Plant Biotechnology, 2014,31(5), 505-509.

Chemical Properties

Cas No. 1913319-59-1 SDF
Canonical SMILES OC1=C(O)C=C2C(C3=CC=C(O)C=C3OC[C@](O)(CC4=CC(O)=C(O)C=C4C5=CC=C(O)C=C5OC[C@@](CO)(O)C2)CO)=C1
分子式 C32H32O12 分子量 608.59
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.6431 mL 8.2157 mL 16.4314 mL
5 mM 0.3286 mL 1.6431 mL 3.2863 mL
10 mM 0.1643 mL 0.8216 mL 1.6431 mL
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Research Update

[Preparation of brazilein from Caesalpinia sappan by high performance countercurrent chromatography]

Se Pu 2020 Dec 8;38(12):1363-1368.PMID:34213250DOI:10.3724/SP.J.1123.2020.03016

Brazilein is among the main chemical constituents of Caesalpinia sappan. It has diverse pharmacological activities. Modern pharmacological studies have shown that the compound has antitumor, anti-inflammatory, antibacterial, antioxidant, immunomodulatory, and other pharmacological activities. Brazilein is often used as a stain in various industries. The separation of brazilein by traditional column chromatography will not only result in contamination of the chromatographic column materials, but also lead to loss of the active ingredient. Countercurrent chromatography is an advanced liquid-liquid chromatographic separation technique. It has been widely used for natural product separation and isolation as it offers several advantages, such as low solvent consumption, a highly selective solvent system, and high recoveries. Typical countercurrent chromatography techniques include centrifugal partition chromatography (CPC), high-speed countercurrent chromatography (HSCCC), and high performance countercurrent chromatography (HPCCC). It is well known that choosing a suitable solvent system is vital in countercurrent separation. Therefore, two methods were introduced for choosing a suitable solvent system. One is the generally useful estimation of solvent systems (GUESS) method, which employs thin-layer chromatography (TLC) to identify a suitable solvent system with minimal labor for the rapid purification of target compounds, and another is the Shake-Flash method. The solvent system could be determined by observing the distribution of the sample in the upper and lower phases. Two kinds of solvent systems were screened using the TLC-GUESS and Shake-Flash methods, and tested through the analysis mode of the HPCCC instrument. The results showed that chloroform-methanol-water (4:3:2, v/v/v) was the optimal solvent system for HPCCC separation. A total of 15.2 mg of brazilein and 5.7 mg of Caesappanin C were obtained from an ethyl acetate extract with high purities (95.6% and 89.0%, analyzed by HPLC) in one step using the preparation mode of HPCCC, the reversed-phase liquid chromatography mode with the apparatus rotated at 1600 r/min, a flow rate of 10 mL/min, separation temperature of 25℃, and detection wavelength of 285 nm. Their structures were determined by spectroscopic and spectrometric analyses. Brazilein stained the solid packing material in the column and was difficult to elute. The results showed that the use of HPCCC for the separation of brazilein can not only prevent the loss of target active ingredients in Caesalpinia sappan, but also shorten the separation and purification times and improve the operating efficiency. Therefore, HPCCC can be used for the separation and preparation of other pigment compounds in Caesalpinia sappan and other dye plants.