Carvacrol
(Synonyms: 香芹酚) 目录号 : GC35612A monoterpene with diverse biological activities
Cas No.:499-75-2
Sample solution is provided at 25 µL, 10mM.
Carvacrol is a monoterpene that has been found in O. vulgare, and has diverse biological activities.1 It induces currents in HEK293 cells expressing mouse transient receptor potential vanilloid 3 (TRPV3) or rat TRP ankyrin A1 (TRPA1) when used at concentrations of 500 and 250 ?M, respectively.2 It also inhibits constitutive activation of TRP melastatin 7 (TRPM7) expressed in HEK293 cells (IC50 = 306 ?M).3 Carvacrol is active against various strains of P. aeruginosa (MICs = 0.3-0.13 ?g/ml).4 It decreases rat brain, liver, and kidney levels of malondialdehyde (MDA), as well as increases superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), and catalase activities in the same tissues when administered at a dose of 40 mg/kg.5 Carvacrol (15 mg/kg) decreases the number of liver tumor nodules in a rat model of diethylnitrosamine-induced hepatocarcinogenesis.6 Formulations containing carvacrol have been used as flavoring agents.
1.Sharifi-Rad, M., Varoni, E.M., Iriti, M., et al.Carvacrol and human health: A comprehensive reviewPhytother. Res.32(9)1675-1687(2018) 2.Xu, H., Delling, M., Jun, J.C., et al.Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channelsNat. Neurosci.9(5)628-635(2006) 3.Parnas, M., Peters, M., Dadon, D., et al.Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channelsCell Calcium45(3)300-309(2009) 4.Cox, S.D., and Markham, J.L.Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compoundsJ. Appl. Microbiol.103(4)930-936(2007) 5.Samarghandian, S., Farkhonden, T., Samini, F., et al.Protective effects of carvacrol against oxidative stress induced by chronic stress in rat's brain, liver, and kidneyBiochem. Res. Int.2645237(2016) 6.Jayakumar, S., Madankumar, A., Asokkumar, S., et al.Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in ratsMol. Cell Biochem.360(1-2)51-60(2012)
Cas No. | 499-75-2 | SDF | |
别名 | 香芹酚 | ||
Canonical SMILES | OC1=CC(C(C)C)=CC=C1C | ||
分子式 | C10H14O | 分子量 | 150.22 |
溶解度 | Insoluble in Water; ≥28.1 mg/mL in EtOH; ≥28.8 mg/mL in DMSO | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 6.6569 mL | 33.2845 mL | 66.569 mL |
5 mM | 1.3314 mL | 6.6569 mL | 13.3138 mL |
10 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet