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Chasmanine Sale

(Synonyms: 展花乌头宁) 目录号 : GC35671

Chasmanine 是一种从 Aconitum crassicaule 根中分离的生物碱类化合物。

Chasmanine Chemical Structure

Cas No.:5066-78-4

规格 价格 库存 购买数量
5 mg
¥5,220.00
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产品描述

Chasmanine is an alkaloid isolated from the roots of Aconitum crassicaule[1].

[1]. Fengpeng W, et al. Alkaloids from roots of Aconitum crassicaule. Planta Med. 1981 Aug;42(8):375-9.

Chemical Properties

Cas No. 5066-78-4 SDF
别名 展花乌头宁
Canonical SMILES CO[C@@H]1C(C(N(CC)C2)C3[C@@H]4OC)([C@@](C[C@@]5([H])[C@@H]6O)([H])[C@@]6([H])[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]2(COC)CC1
分子式 C25H41NO6 分子量 451.6
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2143 mL 11.0717 mL 22.1435 mL
5 mM 0.4429 mL 2.2143 mL 4.4287 mL
10 mM 0.2214 mL 1.1072 mL 2.2143 mL
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Research Update

[Diterpenoid alkaloids from roots of Aconitum kongboense]

Zhongguo Zhong Yao Za Zhi 2021 Sep;46(17):4424-4432.PMID:34581046DOI:10.19540/j.cnki.cjcmm.20210622.201.

The chemical constituents from the roots of Aconitum kongboense were studied. Twenty-five diterpenoid alkaloids were isolated from the 95% methanol extract of the roots of A. kongboense by silica gel, reverse-phase silica gel and basic alumina column chromatography. They included a new aconitine-type diterpenoid alkaloid, named as kongboensenine(1), and twenty-four known ones(2-25), i.e., acotarine F(2), acotarine G(3), 14-acetyltalatisamine(4), talatisamine(5), indaconitine(6), yunaconitine(7), Chasmanine(8), 6-epi-foresticine(9), homochasmanine(10), 8-deacetyl-yunaconitine(11), chasmaconitine(12), ajaconine(13), franchetine(14), ezochasmanine(15), crassicautine(16), 14-O-deacylcrassicausine(17), genicunine A(18), falconeridine(19), sachaconitine(20), liljestrandisine(21), 8-methyl-14-acetyltalatisamine(22), kongboendine(23), 14-benzoylchasmanine(24) and pseudaconine(25). Their structures were elucidated by common spectroscopic methods including high-resolution electrospray ionization mass spectrometry(HR-ESI-MS) and nuclear magnetic resonance(NMR) techniques. Compounds 2-4, 10, 13, 15-19 and 21-22 were isolated from this plant for the first time. Experimental results showed that all compounds did not have a significant inhibitory activity against acetylcholinesterase(AChE).

Alkaloids from Delphinium staphisagria

J Nat Prod 2000 Aug;63(8):1136-9.PMID:10978212DOI:10.1021/np990453l.

Three new diterpenoid alkaloids, isoazitine (1), 19-oxodihydroatisine (2), and 22-O-acetyl-19-oxodihydroatisine (3), and eight known alkaloids-azitine (4), dihydroatisine (5), delphinine, neoline, bullatine C (14-acetylneoline), Chasmanine, 14-acetylchasmanine, and the quaternary base atisinium chloride (7)-were isolated from the aerial parts of Delphinium staphisagria. Structures of the new alkaloids were established mainly by 1D and 2D NMR spectroscopy, including (1)H COSY, HMQC, HMBC, and ROESY. The (1)H and (13)C NMR data for alkaloids 4 and 5 are also reported.

A new C19-diterpenoid alkaloid in Aconitum georgei Comber

Nat Prod Res 2022 Aug 1;1-6.PMID:35913407DOI:10.1080/14786419.2022.2104276.

Nine diterpenoid alkaloids were isolated from Aconitum georgei Comber belonging to the genus Aconitum in Ranunculaceae family. Their structures were determinated by using HR-ESI-MS and 1 D/2D NMR spectra as geordine (1), yunaconitine (2), Chasmanine (3), crassicauline A (4), forestine (5), pseudaconine (6), 14-acetylalatisamine (7), austroconitine B (8), and talatisamine (9). Among them, compound 1 is a previously undescribed aconitine-type C19-diterpenoid alkaloid, and compounds 3, and 5-9 have not previously been isolated from this species. The results of in vitro experiments indicated that new compound 1 possesses mild anti-inflammatory activity, which inhibited the production of NO in LPS-activated RAW 264.7 cells with an inhibition ratio of 29.75% at 50 μM.

Diterpenoid alkaloids from the Chinese traditional herbal "Fuzi" and their cytotoxic activity

Molecules 2012 May 4;17(5):5187-94.PMID:22628040DOI:10.3390/molecules17055187.

Ten diterpenoid alkaloids, including eight aconitine-type C₁₉-diterpenoid alkaloids and two hetisine-type C₂₀-diterpenoid alkaloids, were isolated from the secondary roots of Aconitum carmichaeli Debx., known as "Fuzi" in Chinese traditional herbal medicine. Their structures were established on the basis of their spectroscopic data and comparison with those of the literature. Among these alkaloids, Chasmanine, oxonitine and 15-acetylsongoramine were isolated for the first time from this medicinal plant. The cytotoxic activity of the alkaloids were tested against several cell lines by the MTT method in which aconitine, hypaconitine, mesaconitne and oxonitine were found to strongly inhibit the growth of the HePG2 cell line, which showed that the existence and quantity of the ester groups have a significant influence on the cytotoxicity of the diterpenoid alkaloids.

Alkaloids from roots of Aconitum crassicaule

Planta Med 1981 Aug;42(8):375-9.PMID:17401992DOI:10.1055/s-2007-971658.

From the roots of Aconitum crassicaule, four diterpenoid alkaloids were isolated. Two of these were identified as Chasmanine (5) and yunaconitine (4). The other two, crassicauline A and crassicauline B, are new alkaloids. The structure of crassicauline A, C (35)H (49)O (10)N, has been elucidated as structure (1) on the basis of chemical and spectral data, while the structure of crassicauline B, C (27)H (31)O (4)N, is still to be determined.