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Chlorthalidone Sale

(Synonyms: 氯噻酮) 目录号 : GC35681

A thiazide-like diuretic

Chlorthalidone Chemical Structure

Cas No.:77-36-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥644.00
现货
10mg
¥585.00
现货
50mg
¥1,890.00
现货
100mg 待询 待询
200mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

Description

Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output.1 It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity.2 Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats.3 Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.

1.Roush, G.C., Buddharaju, V., Ernst, M.E., et al.Chlorthalidone: Mechanisms of action and effect on cardiovascular eventsCurr. Hypertens. Rep.15(5)514-521(2013) 2.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008) 3.Cabral, A.M., Carvalhinho, F.B., Vasquez, E.C., et al.Effects of chlorthalidone on ventricular hypertrophy in deoxycorticosterone acetate-salt hypertensive ratsHypertension23(1 Suppl)I180-I184(1994)

化学性质

Cas No. 77-36-1 SDF
别名 氯噻酮
Canonical SMILES O=S(C1=CC(C2(O)NC(C3=C2C=CC=C3)=O)=CC=C1Cl)(N)=O
分子式 C14H11ClN2O4S 分子量 338.77
溶解度 DMSO: ≥ 41 mg/mL (121.03 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.9519 mL 14.7593 mL 29.5186 mL
5 mM 0.5904 mL 2.9519 mL 5.9037 mL
10 mM 0.2952 mL 1.4759 mL 2.9519 mL
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