Coniferyl alcohol

Coniferyl alcohol is a monolignol that has been found in pine sap.¹ It is a precursor in the biosynthesis of lignin and has been used in the synthesis of lignin and a variety of phytochemicals.^2,3 Coniferyl alcohol is an inhibitor of S-adenosyl-homocysteine hydrolase (SAAH) in vitro (IC₅₀ = 34 nM).⁴ It increases the promoter activity of Hsp25 and Hsp70 in NCI H460 cells, as well as protein levels of Hsf1, Hsp27, and Hsp70 in L132 human lung fibroblast cells when used at a concentration of 3 ?M.⁵ It also prevents cell death of Hsf1^+/+, but not Hsf1^-/-, mouse embryonic fibroblasts induced by paclitaxel , cisplatin , or ionizing radiation (IR), and inhibits IR-induced bone marrow damage in mice when administered at a dose of 10 mg/kg.

1.Schwalbe, C.G., and Neumann, K.E.New bark (and sap) of wood of spruce, pine and red beechCellulose-Chemie11113-128(1930) 2.Watts, H.D., Mohamed, M.N., and Kubicki, J.D.Evaluation of potential reaction mechanisms leading to the formation of coniferyl alcohol α-linkages in lignin: A density functional theory studyPhys. Chem. Chem. Phys.13(47)20974-20985(2011) 3.Lv, Y., Cheng, X., Wu, D., et al.Improving bioconversion of eugenol to coniferyl alcohol by in situ eliminating harmful H2O2Bioresour. Technol.267578-583(2018) 4.Hao, W., Li, Y., Shan, Q., et al.Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitorsJ. Enzyme Inhib. Med. Chem.32(1)1209-1215(2017) 5.Choi, S.-K., Mun, G.-I., Choi, E., et al.The conjugated double bond of coniferyl aldehyde is essential for heat shock factor 1 mediated cytotoprotectionJ. Nat. Prod.80(8)2379-2383(2017)