Continentalic acid
(Synonyms: 长白楤木酸) 目录号 : GC35729
A diterpenic acid with diverse biological activities
Cas No.:19889-23-7
Sample solution is provided at 25 µL, 10mM.
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Continentalic acid is a diterpenic acid that has been found in A. continentalis and has diverse biological activities.1,2,3,4 It is active against methicillin-susceptible S. aureus (MSSA) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 8 and 8-16 ?g/ml, respectively).1 Continentalic acid (200 ?M) induces apoptosis in U-2932, OCI-LY1, and Ramos (RA 1) B cell lymphoma cells.2 In vivo, continentalic acid (50 mg/kg) decreases blood glucose levels, total body weight, and serum triglyceride, total cholesterol, and LDL levels, as well as increases serum HDL levels in a rat model of diabetes induced by alloxan .3 It also improves renal function and decreases renal malondialdehyde (MDA) and peroxidase levels, nitric oxide (NO) production, and neutrophil infiltration in a mouse model of E. coli- and LPS-induced renal injury.4
1.Jeong, S.-I., Han, W.-S., Yun, Y.-H., et al.Continentalic acid from Aralia continentalis shows activity against methicillin-resistant Staphylococcus aureusPhytother. Res.20(6)511-514(2006) 2.Jeon, B.-E., Kwon, C.-S., Lee, J.-E., et al.Anticancer activity of continentalic acid in B-cell lymphomaMolecules26(22)6845(2021) 3.Liaquat, I., Khan, A.-U., and Khan, S.Pharmacological evaluation of continentalic acid for antidiabetic potentialBiomed. Pharmacother.138111411(2021) 4.Khan, A.M., Khan, A.U., Ali, H., et al.Continentalic acid exhibited nephroprotective activity against the LPS and E. coli-induced kidney injury through inhibition of the oxidative stress and inflammationInt. Immunopharmacol.80106209(2020)
| Cas No. | 19889-23-7 | SDF | |
| 别名 | 长白楤木酸 | ||
| Canonical SMILES | C[C@]12[C@@](CCC3=C[C@](C=C)(C)CC[C@@]23[H])([H])[C@@](C)(CCC1)C(O)=O | ||
| 分子式 | C20H30O2 | 分子量 | 302.45 |
| 溶解度 | DMSO : 100 mg/mL (330.63 mM; Need ultrasonic) | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3063 mL | 16.5317 mL | 33.0633 mL |
| 5 mM | 0.6613 mL | 3.3063 mL | 6.6127 mL |
| 10 mM | 0.3306 mL | 1.6532 mL | 3.3063 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet