Cyhalofop
(Synonyms: 氰氟草酸; Cyhalofop acid) 目录号 : GC35786
Cyhalofop是一种除草剂。
Cas No.:122008-78-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cyhalofop(Cyhalofop acid) is a recently registered herbicide from the aryloxyphenoxy propionate group in India to control a wide range of grass weed species at various growth stages in rice crop.
[1]. Kumar B, et al. Evaluation of harvest residues of Cyhalofop-butyl in paddy soil. Bull Environ Contam Toxicol. 2012 Aug;89(2):344-7.
| Cas No. | 122008-78-0 | SDF | |
| 别名 | 氰氟草酸; Cyhalofop acid | ||
| Canonical SMILES | C[C@@H](OC1=CC=C(OC2=CC=C(C#N)C=C2F)C=C1)C(O)=O | ||
| 分子式 | C16H12FNO4 | 分子量 | 301.27 |
| 溶解度 | DMSO: ≥ 31 mg/mL (102.90 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3193 mL | 16.5964 mL | 33.1928 mL |
| 5 mM | 0.6639 mL | 3.3193 mL | 6.6386 mL |
| 10 mM | 0.3319 mL | 1.6596 mL | 3.3193 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Transcriptome analysis reveals hepatotoxicity in zebrafish induced by Cyhalofop‑butyl
Aquat Toxicol 2022 Nov;252:106322.PMID:36240591DOI:10.1016/j.aquatox.2022.106322.
Cyhalofop‑butyl is a highly effective aryloxyphenoxypropionate herbicide and widely used for weed control in paddy fields. With the increasing residue of Cyhalofop‑butyl, it poses a threat to the survival of aquatic organisms. Here, we investigated the effect of Cyhalofop‑butyl on zebrafish to explore its potential hepatotoxic mechanism. The results showed that Cyhalofop‑butyl induced hepatocyte degeneration, vacuolation and necrosis of larvae after embryonic exposure for 4 days and caused liver atrophy after 5 days. Meanwhile, the activities of enzymes related to liver function were significantly increased by 0.2 mg/L Cyhalofop‑butyl and higher, such as alanine transaminase (ALT) and aspartate transaminase (AST). And the contents of triglyceride (TG) involved in lipid metabolism were significantly decreased by 0.4 mg/L cyhalofop-buty. The expression of genes related to liver development was also significantly down-regulated. Furthermore, transcriptome results showed that the pathways involved in metabolism, immune system and endocrine system were significantly impacted, which may be related to hepatoxicity. To sum up, the present study demonstrated the hepatoxicity caused by cyhalofop-buty and its underlying mechanism. The results may provide new insights for the risk of Cyhalofop‑butyl to aquatic organisms and new horizons for the pathogenesis of hepatotoxicity.
Cyhalofop-p-butyl mobility and distribution of residues in soil at various depths
J Environ Sci Health B 2014;49(6):391-9.PMID:24762176DOI:10.1080/03601234.2014.894762.
This study was conducted to evaluate cyhalofop-p-butyl mobility in a sandy loam soil and subsequent distribution of residues at various depths under field conditions. Soil samples were taken from 0 to 150 cm depths at 3-90 d after rains in lysemeter of 1 and 2 m depths. Cyhalofop-p-butyl application at two rates and subsequent precipitation had a significant impact on soil, physico-chemical properties and herbicide mobility. Precipitation caused substantial mobility of cyhalofop-p-butyl in the soil and 1.1-7.6 μg L(-1) of cyhalofop-p-butyl was found in leachates. Cyhalofop-p-butyl residues in the leachates were probably due to preferential flow through the soil. Cyhalofop-p-butyl residues were detected in significant amounts from the soil up to 10 d, later, residues were found below the detection limit but its three transformation products viz., Cyhalofop acid, diacid, and phenol were detected.
Enhanced metabolism confers a high level of cyhalofop-butyl resistance in a Chinese sprangletop (Leptochloa chinensis (L.) Nees) population
Pest Manag Sci 2021 May;77(5):2576-2583.PMID:33497007DOI:10.1002/ps.6297.
Background: Chinese sprangletop (Leptochloa chinensis (L.) Nees) is one of main grass weeds invading Chinese rice fields. The target-site resistance (TSR) of cyhalofop-butyl have been widely reported in L. chinensis populations, but the non-target-site resistance (NTSR) mechanisms have not yet been well-characterized. This study aims to investigate the likely NTSR in a cyhalofop-butyl-resistant L. chinensis population (YZ-R), which was collected from Yangzhou city, Jiangsu Province, China. Results: Dose-response assays showed the YZ-R population exhibited 191.6-fold resistance to cyhalofop-butyl, compared to the susceptible population (YZ-S). This resistance is not target-site based, because no mutations in the two ACCase genes were detected in the YZ-R plants compared to the YZ-S plants, and the ACCase genes expression levels were similar in YZ-S and YZ-R plants. In addition, the cytochrome P450 inhibitor malathion and piperonyl butoxide (PBO), and glutathione S-transferase (GST) inhibitor 4-chloro-7-nitrobenzoxadiazole (NBD-Cl) did not significantly reverse cyhalofop-butyl resistance in the YZ-R population. However, liquid chromatography-mass spectrometry (LC-MS) analysis indicated that the metabolic rates of Cyhalofop acid in YZ-R plants was significantly faster (5 to 10- fold) than in YZ-S plants. Furthermore, the YZ-R population showed no cross-resistance to other ACCase-inhibiting herbicides. Conclusion: These results indicated that cyhalofop-butyl resistance in the YZ-R population is due to non-target-site based enhanced herbicide metabolism. Resistance in this population is likely involved in a specific detoxification enzyme, with possible high catalytic efficiency and strong substrate specificity, therefore leading to high-level and single resistance to cyhalofop-butyl. © 2021 Society of Chemical Industry.
Evaluation of harvest residues of Cyhalofop-butyl in paddy soil
Bull Environ Contam Toxicol 2012 Aug;89(2):344-7.PMID:22729719DOI:10.1007/s00128-012-0701-0.
Cyhalofop-butyl is a recently registered herbicide from the aryloxyphenoxy propionate group in India to control a wide range of grass weed species at various growth stages in rice crop. Field experiment with rice variety Pusa Sugandh 5 was conducted at IARI, New Delhi. Rice crop was sprayed thrice with cyhalofopa-butyl at 40, 60 and 80 g ha(-1) at the 10, 20 and 30 DAS. Harvest soil samples were extracted and analysed for cyhalofop-butyl and Cyhalofop acid residues by HPLC using CH(3)OH:H(2)O (80:20) mobile phase at a flow rate of 1 mL min(-1) at 240 nm wavelength using PDA detector. In harvest soil the residues were below the detectable limits.
Determination and study on dissipation and residue determination of cyhalofop-butyl and its metabolite using HPLC-MS/MS in a rice ecosystem
Environ Monit Assess 2014 Oct;186(10):6959-67.PMID:25007772DOI:10.1007/s10661-014-3902-7.
Cyhalofop-butyl is an aryloxyphenoxypropionate postemergence herbicide with good control of barnyard grass in rice paddies. In this study, method for the determination of cyhalofop-butyl and its metabolite was developed with high-performance liquid chromatography tandem mass spectrometry. Dissipation and residue levels of cyhalofop-butyl and its metabolite in rice ecosystems were also investigated. Recoveries and relative standard deviations of cyhalofop-butyl and Cyhalofop acid in six matrices at three spiking levels ranged from 76.1 to 107.5% and 1.1 to 8.2%, respectively. The limit of quantitation (LOQ) of cyhalofop-butyl and Cyhalofop acid was 0.01 mg/kg in paddy water, paddy soil, rice plant, rice straw, rice hulls, and husked rice. For field experiments, the results showed that cyhalofop-butyl degraded to Cyhalofop acid quickly, and the half-lives of Cyhalofop acid in paddy water, paddy soil, and rice plant were 1.01-1.53, 0.88-0.97, and 2.09-2.42 days, respectively. Ultimate residues of cyhalofop-butyl and its metabolite in the rice samples were not detectable or below 0.01 mg/kg at harvest.