Dehydrocorydaline chloride

Dehydrocorydaline is an alkaloid that has been found in C. yanhusuo and has diverse biological activities.^1,2,3,4 It is herbicidal against duckweed (L. minor) when used at a concentration of 10 ppm in the growth medium.¹ Dehydrocorydaline inhibits serotonin reuptake by organic cation transporter 2 (OCT2) and dopamine reuptake by OCT3 (IC₅₀s = 0.137 and 0.354 ?M, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes.² In vivo, dehydrocorydaline (1.5 and 3 mg/kg) decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress. Dehydrocorydaline (10 mg/kg) reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain.^3,4

1.Iwasa, K., Moriyasu, M., and Nader, B.Fungicidal and herbicidal activities of berberine related alkaloidsBiosci. Biotechnol. Biochem.64(9)1998-2000(2000) 2.Jin, L., Zhou, S., Zhu, S., et al.Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transportersEur. J. Pharmacol.864172725(2019) 3.Yin, Z.-Y., Li, L., Chu, S.-S., et al.Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokinesSci. Rep.627129(2016) 4.Huo, W., Zhang, Y., Liu, Y., et al.Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotypeMol. Pain141744806918781733(2018)